华法令阻凝剂系统的概述及其药物和食物交互。

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霍尔布鲁克,佩雷拉JA, Labiris R,麦当劳H, Douketis JD,克洛泽M,威尔斯PS

华法令阻凝剂系统的概述及其药物和食物交互。

拱实习生地中海。2005年5月23日,165 (10):1095 - 106。

PubMed ID

15911722 (在PubMed

]

文摘

背景:华法林是一个高度有效的口服抗凝剂,但它的使用是有限的恐惧的出血。药物和食物经常被援引的相互作用引起的不良事件与华法林。我们提供一个更新的系统概述质量、临床效果,这些报道的相互作用的重要性。资料来源:MEDLINE和TOXLINE、IPA和EMBASE数据库从1993年10月到2004年3月。数据库搜索关键字华必威国际app法林与药物的相互作用结合起来,草药,中草药,food-drug交互。研究选择:合格的文章包含原始报告的华法林药物或食品在人体的相互作用。非英语文章包含足够的信息是否可以被抽象。数据提取:报告被评为由2调查人员交互方向,独立临床严重程度和质量的证据。质量的证据是基于之前验证因果关系标准和研究设计。数据综合:642年的引文检索,181合格文章包含原始报告120年药物或食物。 Inter-rater agreement was excellent, with weighted kappa values of 0.84 to 1.00. Of all reports, 72% described a potentiation of warfarin's effect and 84% were of poor quality, 86% of which were single case reports. The 31 incidents of clinically significant bleeding were all single case reports. Newly reported interactions included celecoxib, rofecoxib, and herbal substances, such as green tea and danshen. CONCLUSIONS: The number of drugs reported to interact with warfarin continues to expand. While most reports are of poor quality and present potentially misleading conclusions, the consistency of reports of interactions with azole antibiotics, macrolides, quinolones, nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors, selective serotonin reuptake inhibitors, omeprazole, lipid-lowering agents, amiodarone, and fluorouracil, suggests that coadministration with warfarin should be avoided or closely monitored. More systematic study of warfarin drug interactions in patients is urgently needed.

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药物

华法令阻凝剂