从蔗糖Nonencapsulated脑膜炎奈瑟氏菌菌株生产支链淀粉:改变对脑膜炎奈瑟菌之间的分化和n . polysaccharea概念。
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朱P,曾荫权RS,蔡厘米
从蔗糖Nonencapsulated脑膜炎奈瑟氏菌菌株生产支链淀粉:改变对脑膜炎奈瑟菌之间的分化和n . polysaccharea概念。
中国Microbiol。2003年1月,41 (1):273 - 8。
- PubMed ID
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12517860 (在PubMed]
- 文摘
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脑膜炎奈瑟菌脑膜炎球菌败血症和脑膜炎的病原体。奈瑟氏菌属polysaccharea是不致病的物种。n polysaccharea能够使用蔗糖生产支链淀粉,starch-like多糖,它区别于脑膜炎奈瑟菌致病性的物种。本文提供的数据表明,这可能是一个不够标准来区分这两个物种。的nonencapsulated奈瑟氏菌属菌株93246表示表型的支链淀粉生产n . polysaccharea相似。然而,脑膜炎奈瑟菌菌株93246反应血清型4和serosubtype P1.14脑膜炎奈瑟菌单克隆抗体,显示L1 (8) lipo-oligosaccharide immunotype。进一步分析四个基因位点在93246株,结果是与脑膜炎奈瑟菌7株相比,13 n . polysaccharea菌株和2 n .球菌菌株。三个基因位点的探讨,和93246年应变lgt-1脑膜炎奈瑟菌在相同。特别是德说。基因编码polysialyltransferase负责脑膜炎奈瑟菌的生物合成B组胶囊中检测出93246株。这说的移码突变基因灭活的poly (C),这使得脑膜炎奈瑟菌菌株93246与其他nonencapsulated菌株。 As expected, the ams gene encoding amylosucrase, responsible for production of amylopectin from sucrose, was detected in strain 93246 and all 13 N. polysaccharea strains but not in N. meningitidis and N. gonorrhoeae strains. These data suggest that strain 93246 is nonencapsulated N. meningitidis but has the ability to produce extracellular amylopectin from sucrose. The gene for amylopectin production in strain 93246 was likely imported from N. polysaccharea by horizontal genetic exchange. Therefore, we conclude that genetic analysis is required to complement the traditional phenotypic classification for the nonencapsulated Neisseria strains.