分子克隆和基因的染色体分配人类Zn-alpha 2-glycoprotein。
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Ueyama H,邓HX, Ohkubo我
分子克隆和基因的染色体分配人类Zn-alpha 2-glycoprotein。
生物化学,1993年12月7日,32 (48):12968 - 76。
- PubMed ID
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8241150 (在PubMed]
- 文摘
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包含人类基因组克隆Zn-alpha 2-glycoprotein基因被孤立。两个的功能基因重叠,和其他四个是两个不同的假基因(1和2)保留exon-intron组织。完整的功能性基因的DNA序列(9.3 kb)和它的5 '和3 '侧翼区(分别为5.3和0.1 kb)。基因是由四个外显子;第一外显子是5 '非翻译区,信号序列,和前六个氨基酸;第二,因为域;第三,域B;和第四域C和3 '非翻译区。5 '侧翼区域包含一个TATA盒,一只猫盒子,一个八聚物序列,和三种可能的Spl-binding网站。十和三份Alu重复DNA中发现基因和5 '侧翼地区,分别和他们占据30%的基因。 The nucleotide sequences around the exons of pseudogene 1 were also determined; they had high homology (90-91%) with the corresponding region of the functional gene. Southern blot analysis suggested that there are only three genes, including nonfunctional ones, for Zn-alpha 2-glycoprotein in humans. The gene (ZA2G) was mapped to human chromosome band 7q22.1 by fluorescence in situ hybridization.