酷(TRPM8)和热(TRPV1)受体在膀胱和男性生殖道。

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哈亚希斯坦RJ桑托斯年代,Nagatomi J, Y, Minnery BS,泽维尔M,帕特尔,纳尔逊JB, Futrell WJ, Yoshimura N,总理MB, De米格尔F

酷(TRPM8)和热(TRPV1)受体在膀胱和男性生殖道。

9月杂志。2004;172 (3):1175 - 8。

PubMed ID

15311065 (在PubMed

]

文摘

目的:膀胱过动症症状由于各种病因已经成功处理辣椒素的脱敏草酸受体TRPV1温度敏感。TRPM8最近另一个温度敏感受体,激活薄荷醇,气温凉爽(8 c - 28 c)是描述可能提出的很酷的受体,至少部分中介在诊断膀胱回应冰水测试。我们定义了网站TRPM8 mRNA和蛋白表达和TRPV1在老鼠和人类泌尿生殖系统。材料与方法:前列腺、睾丸、阴茎、膀胱和背根神经节组织获得了老鼠。前列腺、睾丸、细精管,阴茎海绵体,龟头,覆盖龟头皮肤,阴囊皮肤和膀胱是来自人类的病人。逆转录-聚合酶链反应完成,使用物种特定引物TRPM8和TRPV1。免疫荧光染色TRPM8表现在大鼠组织以及在人类细胞移行细胞培养。结果:TRPM8和TRPV1 mRNA在所有大鼠组织中检测到。人类样本演示TRPM8 mRNA在前列腺、睾丸细精管,阴囊皮肤和膀胱。没有确定人类阴茎海绵体TRPM8 mRNA,龟头或覆盖龟头皮肤。 Separation of layers in human bladder demonstrated mRNA for TRPM8 only in the urothelium and not in the detrusor. Immunofluorescence location of TRPM8 was found in rat prostate, DRG and bladder, and in human urothelial cells in culture. TRPV1 mRNA was detected in all human genitourinary tract tissues. CONCLUSIONS: These results demonstrate that mRNA and protein for TRPM8 exist in multiple genitourinary organs in the rat and human, and it may be considered a possible new target, as is TRPV1, for the pharmacological treatment of detrusor overactivity or other urological disorders.

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药物靶点

药物	目标	类	生物	药理作用	行动
Levomenthol	瞬时受体电位阳离子通道亚科8 M成员	蛋白质	人类	是的	诱导物	细节