分析5-HT1A受体参与大鼠被动回避。
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Misane我,约翰逊C, Ogren
分析5-HT1A受体参与大鼠被动回避。
Br J杂志。1998年10月,125 (3):499 - 509。
- PubMed ID
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9806333 (在PubMed]
- 文摘
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1。5-HT2A / 2 c受体激动剂强加于人的影响,选择性5-HT1A兴奋剂NDO 008 (3-dipropylamino-5-hydroxychroman)的两个对映体选择性5-HT1A兴奋剂8-OH-DPAT (R (+) 8-OH-DPAT和S (-) 8-OH-DPAT)研究了在一个分步雄性大鼠被动回避(PA)测试。2。5-HT1A受体激动剂注射前培训(空调)产生剂量依赖性考评的损伤检查24 h后时保留。R (+) 8-oh-dpat四倍比S(-)更有效8-oh-dpat导致PA保留的障碍。NDO 008和的两个对映体8-OH-DPAT诱导剂量范围的5 -羟色胺综合征产生抑制PA响应,因此,指示激活突触后5-HT1A受体。3所示。无论是NDO 008 R (+) 8-oh-dpat诱导head-twitches,行为归因于突触后5-HT2A受体的刺激做出的反应。相比之下,罗伯特诱导head-twitches在0.01毫克公斤(1)剂量而200倍剂量被要求生产PA保留的一个重要障碍。4所示。 The impairment of PA retention induced by both NDO 008 and R(+)-8-OH-DPAT was fully blocked by the active S(+)- enantiomer of the selective 5-HT1A antagonist WAY 100135 and the mixed 5-HT1A/beta-adrenoceptor antagonist L(-)-alprenolol. In contrast, the mixed 5-HT2A/2C antagonists ketanserin and pirenperone were found to be ineffective. Moreover, the beta2-adrenoceptor antagonist ICI 118551, the beta-antagonist metoprolol as well as the mixed beta-adrenoceptor blocker D(+)-alprenolol all failed to modify the deficit of PA retention by NDO 008 and R(+)-8-OH-DPAT. None of the 5-HT1A or 5-HT2A/2C receptor antagonists tested or the beta-blockers altered PA retention by themselves. 5. A 3 day pretreatment procedure (200+100+100 mg kg(-1)) with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA) did not alter PA retention and did not prevent the inhibitory action of the 5-HT1A agonists, indicating that their effects on PA do not depend on endogenous 5-HT. 6. The effects of NDO 008 on PA were also studied using a state-dependent learning paradigm. NDO 008 was found to produce a disruption of PA when given either prior to training or retention or both prior to training and retention but it failed to affect PA retention when given immediately after training. .7 These findings indicate that the deficit of passive avoidance retention induced by the 5-HT1A agonists is mainly a result of stimulation of postsynaptic 5-HT1A receptors but not 5-HT2A receptors. The 5-HT1A receptor stimulation appears to interfere with learning processes operating at both acquisition and retrieval.