遗传methicillin-susceptible台面式晶体管地区组织和耐甲氧西林葡萄球菌菌株sciuri。
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吴,de Lencastre H,托马斯
遗传methicillin-susceptible台面式晶体管地区组织和耐甲氧西林葡萄球菌菌株sciuri。
J Bacteriol。1998年1月,180 (2):236 - 42。
- PubMed ID
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9440511 (在PubMed]
- 文摘
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耐甲氧西林金黄色葡萄球菌的同族体基因台面式晶体管最近被证明是无处不在的葡萄球菌sciuri独立隔离的动物物种。台面式晶体管基因侧翼同族体和地区它是克隆和测序四株s sciuri:应变K1(写明ATCC 29062),代表美国sciuri无性系种群。sciuri;两个菌株(K3和K8)代表美国sciuri无性系种群。rodentius;的代表和应变K11 sciuri无性系种群。carnaticum。甲氧西林菌株K1和K11容易,而株K3异构阻力和美丽。台面式晶体管基因的菌株K1和K11两份台面式晶体管(mecA1)出现在应变K3在台面式晶体管基因几乎相同的DNA序列,相似的基因组织侧翼地区。相比之下,台面式晶体管的单一副本应变K8第二份台面式晶体管(mecA2)在应变K3台面式晶体管DNA序列相同的金黄色葡萄球菌的梅卡,和台面式晶体管地区这两个菌株也类似于同一地区的金黄色葡萄球菌菌株用于比较。 Interestingly, an open reading frame defining an N-terminal truncated polypeptide, NTORF101, with a high degree of homology to a DNA segment in the hypervariable region of methicillin-resistant S. aureus (and also similar to the Escherichia coli gene ugpQ) was also identified downstream of the mecA homolog of strain K11, representing S. sciuri subsp. carnaticum. The ugpQ-like gene is not present in methicillin-susceptible strains of S. aureus. The presence of such a ugpQ-like gene together with the homolog of mecA in strain K11 supports the speculation that these genetic elements may be evolutionary relatives and/or precursors of the genetic determinant of methicillin resistance in S. aureus.