肠系膜动脉重塑和效果imidapril和irbesartan自发性高血压大鼠。

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王朱z, JM,陈SL

肠系膜动脉重塑和效果imidapril和irbesartan自发性高血压大鼠。

世界杂志。2004年5月15日,10 (10):1471 - 5。

PubMed ID

15133856 (在PubMed

]

文摘

目的:探讨肠系膜动脉的重建和TGF-beta1的表达,c-Jun肠系膜动脉和imidapril和irbesartan重构在自发性高血压大鼠(月)。方法:30月(男/女,21/9),13岁工作,被随机分为3组(3 7雄性老鼠和雌性老鼠每组):月组、imidapril组(imidapril 3毫克/公斤。d是饮用水中14周)和irbesartan集团(irbesartan 50毫克/公斤。d饮用水中被敌人14周)。十均匀纯种京都的老鼠,男性和5雌性,体重206 + / -49克,被选为正常对照组(WKY组)。收缩压是衡量d 1、2、4、6、8、10、12和14在老鼠实验,实验结束时被杀害。血浆血管紧张素ⅱ(Ang II)水平和肠系膜动脉被放射免疫检定法测量。肠系膜动脉的形态学的二级分支被光学显微镜和电子显微镜检查。逆转录聚合酶链反应(rt - pcr)是用于检测转化生长因子TGF-beta1和c-Jun mRNA的表达。结果:与imidapril组和irbesartan组相比,血压显著增加月集团。Angⅱ水平在等离子体和肠系膜动脉月组相同或低于WKY组,并于imidapril高irbesartan组和低组。肠系膜动脉的重建萎缩组主要是明显的在4组。 The ratio of TGF-beta1 absorbed light value to GAPDH absorbed light value in the SHR group was 0.887+/-0.019, which was significantly higher than that in WKY group, imidapril group, and irbesartan group with the ratios of 0.780+/-0.018, 0.803+/-0.005, and 0.847+/-0.017, respectively (P<0.01). Ang II level in plasma and mesenteric arteries in imidapril group was significantly lower than that in irbesartan group (P<0.05). The c-Jun absorbed light value/GAPDH absorbed light value of mesenteric arteries in the SHR group was 0.850+/-0.015, which was significantly higher than that in the WKY, imidapril, and irbesartan groups (0.582+/-0.013, 0.743+/-0.012, and 0.789+/-0.013, respectively, P<0.01), and was significantly lower in imidapril group than in irbesartan group (P<0.05). CONCLUSION: Imidapril and irbesartan can not only control blood pressure but also inhibit mesenteric arteries remodeling and mRNA expression of TGF-beta1, c-Jun in SHR. Imidapril is more effective than irbesartan.

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药物靶点

药物	目标	类	生物	药理作用	行动
Irbesartan	转录因子AP-1	蛋白质	人类	未知的	其他/未知	细节