Terbinafine:回顾它的使用在成年人的甲真菌病。

文章的细节

引用
复制到剪贴板

黑暗的乔丹,斯科特LJ,果阿吉隆坡

Terbinafine:回顾它的使用在成年人的甲真菌病。

是中国新药杂志。2003;4 (1):39 - 65。

PubMed ID
12477372 (在PubMed
]
文摘

Terbinafine、口服和局部活跃的抗真菌的代理,能抑制真菌的主要甾醇的生物合成,麦角固醇,角鲨烯环氧酶的水平。角鲨烯环氧酶抑制导致ergosterol-depleted真菌细胞膜(抑制真菌的作用)和有毒的胞内积累角鲨烯(抑菌作用)。Terbinafine展现了出色的真菌的活动对真菌和变量活动对酵母和non-dermatophyte模具体外。口服后,terbinafine迅速吸收和广泛分布到人体的各个组织包括灌注差钉矩阵。指甲terbinafine浓度检测后1周内开始治疗,持续至少30周后完成治疗。随机、双盲试验显示口腔terbinafine 250毫克/天12或16周更有效比伊曲康唑,氟康唑,灰黄霉素在皮肤真菌脚趾甲的甲真菌病。特别是,在72周的随访,多中心,跨国,L.I.ON。(甲癣Lamisil vs伊曲康唑)研究发现,mycologic治愈率(76 vs 38%的患者经过12周的治疗;81和49%的受惠者经过16周的疗法)和完整的治愈率terbinafine治疗后大约两倍于后伊曲康唑(3或4周期1周400毫克/天的重复每4周)患者的脚趾甲真菌病。此外,L.I.ON。 Icelandic Extension study demonstrated that terbinafine was more clinically effective than intermittent itraconazole to a statistically significant extent at 5-year follow-up. Terbinafine produced a superior complete cure rate (35 vs 14%), mycologic cure rate (46 vs 13%) and clinical cure rate (42 vs 18%) to that of itraconazole. The mycologic and clinical relapse rates were 23% and 21% in the terbinafine group, respectively, compared with 53% and 48% in the itraconazole group. In comparative clinical trials, oral terbinafine had a better tolerability profile than griseofulvin and a comparable profile to that of itraconazole or fluconazole. Post marketing surveillance confirmed terbinafine's good tolerability profile. Adverse events were experienced by 10.5% of terbinafine recipients, with gastrointestinal complaints being the most common. Unlike the azoles, terbinafine has a low potential for drug-drug interactions. Most pharmacoeconomic evaluations have shown that the greater clinical effectiveness of oral terbinafine in dermatophyte onychomycosis translates into a cost-effectiveness ratio superior to that of itraconazole, fluconazole and griseofulvin. CONCLUSION: Oral terbinafine has demonstrated greater effectiveness than itraconazole, fluconazole and griseofulvin in randomized trials involving patients with onychomycosis caused by dermatophytes. The drug is generally well tolerated and has a low potential for drug interactions. Therefore, terbinafine is the treatment of choice for dermatophyte onychomycosis.

DrugBank数据引用了这篇文章

药物
药物靶点
药物 目标 类 生物 药理作用 行动
Terbinafine 角鲨烯单氧酶 蛋白质 人类
没有
抑制剂
 细节
Terbinafine 角鲨烯单氧酶 蛋白质 酵母
是的
抑制剂
 细节