浓度效应关系的积极变时性的和非诺特罗hypokalaemic影响健康育龄妇女。
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清汤T, Meineke我、港口R, Hildebrandt R,冈瑟K, Gundert-Remy U
浓度效应关系的积极变时性的和非诺特罗hypokalaemic影响健康育龄妇女。
51欧元中国新药杂志。1996;(2):153 - 60。
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8911881 (在PubMed]
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目的:分析fenoterol-induced心动过速和低钾血症,最重要和最常见的副作用与β2-adrenoceptor相关受体激动剂在育龄女性。方法:这项研究是进行双盲,随机,安慰剂对照,交叉试验。七岁的健康女性22-38 y,接受静脉输液治疗范围内的非诺特罗在3种不同的利率为表现意涵(0.5,1.0,和2.0 micrograms.min-1)和安慰剂。非诺特罗的血浆浓度的时间课程和钾,和心率分析混合效果pharmacokinetic-pharmacodynamic使用NONMEM (PKPD)建模。结果:血浆浓度时间跟随一个线性两室模型。Fenoterol-induced心动过速被一个线性浓度效应模型与基线。估计基线和斜率参数是78次。最低为1和0.032 beats.min 1.1 - 1.毫克,分别。Fenoterol-induced低钾血症可以描述一个生理间接响应模型包括反馈;估计基础血浆钾浓度为3.93更易。1 - 1和斜率因子fenoterol-induced相对增加钾的排出细胞外空间是6.22 * 10 (4)ng.1 (1)。 CONCLUSION: The estimated population parameters permitted calculation of the expected time course of tachycardia and hypokalaemia in women after the initiation of tocolysis with fenoterol over the clinically relevant concentration range, and prediction of its variability. Based on simulation, our model predicted that a continuous infusion of 2.0 micrograms.min-1 (highest rate examined) would increase heart rate to 113 beats.min-1 at steady state and lower the plasma potassium concentration to 2.77 mmol.1(-1) 1.5 h after beginning the infusion. Thereafter, the plasma potassium concentration would slowly return to normal.