胍乙啶的影响和局部麻醉剂的电刺激老鼠输精管。

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组织者乔伊斯π,Rizzi D,卡洛G, Rowbotham DJ,兰伯特DG

胍乙啶的影响和局部麻醉剂的电刺激老鼠输精管。

Anesth。2002年11月,95(5):1339 - 43,表的内容。

PubMed ID

12401623 (在PubMed

]

文摘

复杂区域疼痛综合征通常对待阻滞交感神经的胍乙啶和局部麻醉在棺材的块。这种治疗的有效性受到质疑。因为局部麻醉剂抑制去甲肾上腺素,我们假设这个变量有效性结果从本地抑制胍乙啶的吸收。在这项研究中,我们测试了这个假设支配同情地通过使用鼠标输精管准备。器官bath-mounted鼠标瓦萨号deferentia电刺激在胍乙啶的缺失和存在,在各种组合丙胺卡因,普鲁卡因和可卡因。丙胺卡因(1毫米)诱导立即抑制抽搐反应(最大100%,2分钟),洗涤后完全逆转。胍乙啶(3 microM)也抑制抽搐在15分钟95% + / - 3%,但这种效果只是部分逆转1 h后洗(33% + / - 12%的控制)。丙胺卡因和胍乙啶添加相结合时,80% + / - 13%的逆转(1 h)。普鲁卡因(300微)产生一个短暂的增加(152% + / - 14%)。当co-incubated胍乙啶(3 microM),抽搐减少到24% + / - 4%的控制和逆转后77% + / - 7% 1 h。可卡因(30 microM)抑制抽搐应对53% + / - 8%,完全逆转的1 h的洗涤。 When co-incubated with guanethidine, the response was reduced to 39% +/- 6% of control and was reversed to 86% +/- 10% after 1 h. In all cases, the reversal produced by the combination was significantly more intense (P < 0.05) than that produced by guanethidine alone. Local anesthetics reduce the sympatholytic actions of guanethidine, and this may explain the variable efficacy of guanethidine in the treatment of complex regional pain syndrome. IMPLICATIONS: In this study, with a sympathetically innervated vas deferens preparation, local anesthetics reduced the efficacy of the sympatholytic guanethidine, questioning its co-administration in the pain clinic.

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药物靶点

药物	目标	类	生物	药理作用	行动
Debrisoquine	Sodium-dependent去甲肾上腺素转运体	蛋白质	人类	是的	诱导物	细节