类风湿关节炎患者血浆四联素水平与疾病活动性

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Kamper EF, Kopeikina LT, Koutsoukos V, Stavridis J

类风湿关节炎患者血浆四联素水平与疾病活动性

风湿病杂志，1997 2月;24(2):262-8。

PubMed ID

9034981 (PubMed视图

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摘要

目的:我们研究了类风湿性关节炎(RA)患者血浆四联素(一种新的纤溶酶原激活调节剂)水平与疾病活动性和其他纤溶变量的关系。方法:采用酶联免疫吸附法(ELISA)定量检测41例RA患者和30例健康对照者血浆中的四联素(TN)、组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制物(PAI-1)，并采用酰胺溶法测定α - 2-抗纤溶酶活性。疾病活动性被确定为一个综合斯托克指数，用于测量类风湿性关节炎的炎症过程。根据疾病活动性斯托克指数(Stoke Index)评分分为3组:A为最低-轻度，1-7为b为中度。8-11: C.严重;12 - 17。结果:患者血浆TN明显低于健康人[9.11 (4.97 ~ 13.49)mg/l, 12.05 (9.50 ~ 13.60) mg/l，中位数(范围);P = 0.0001]。TN随疾病活动性的增加而降低。TN与斯托克指数呈显著负相关。 C-reactive protein and erythrocyte sedimentation rate was found (rs = -0.49, p = 0.0012; rs = -0.44, p = 0.0044; rs = -0.37, p = 0.016, respectively). alpha 2-Antiplasmin activity was elevated in patients compared to healthy subjects [105.0% (53.0-146.0), 70.6% (48.2-124.0), median (range), respectively; p = 0.0001], showing a negative correlation with Stoke Index (rs = -0.38, p = 0.0139). The close positive correlation of TN with alpha 2-antiplasmin (rs = 0.66, p = 0.0001) and the absence of correlation with t-PA and PAI-1 were explained by the involvement of TN and alpha 2-antiplasmin in localized rather than in systemic fibrinolysis. CONCLUSION: Our findings suggest TN plays a role in the pathophysiology of RA and point to the usefulness of TN assessment as a specific fibrinolytic marker in the evaluation of disease activity in patients with RA. The role of TN in the intraarticular regulation of fibrinolysis, important for the expansion of pannus, tissue remodeling and angiogenesis, is discussed.

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药物	目标	种类	生物	药理作用	行动
Tenecteplase	Tetranectin	蛋白质	人类	未知的	不可用	细节