Pantoprazole:一个更新的药理性质和治疗用途的管理acid-related紊乱。

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Pantoprazole:一个更新的药理性质和治疗用途的管理acid-related紊乱。

药。2003;63(1):101 - 33所示。

PubMed ID

12487624 (在PubMed

]

文摘

Pantoprazole (Protonix)是一个不可逆转的质子泵抑制剂(PPI)减少胃酸分泌。结合两种抗菌药物(最常见的甲硝哒唑,克拉霉素、阿莫西林)第6 - 14天,pantoprazole 40毫克每日两次生产幽门螺杆菌根除率71 - 93.8% (intent-to-treat (ITT)或修改ITT分析)没有已知抗菌耐药的病人。Pantoprazole-containing奥美拉唑三联疗法至少是尽可能有效和类似的功效lansoprazole-containing三联疗法在大型试验。治疗中度到重度gastro-oesophageal反流病(GORD),口服pantoprazole 40毫克/天是有效的与其他质子泵抑制剂(用兰索拉唑奥美拉唑、奥美拉唑多个单元颗粒系统和唑)和更有效的比组胺H(2)拮抗剂。Pantoprazole 20毫克/天提供有效的GORD患者粘膜愈合和轻度食管炎。静脉注射pantoprazole 40毫克/天可用于患者无法接受口服药物治疗。口服pantoprazole 20 - 40毫克/天长达24个月在大多数患者愈合GORD预防复发。初步数据显示,口服pantoprazole 20或40毫克/天是有效的治疗和预防非甾体抗炎药(非甾体抗炎药)-相关溃疡、静脉和静脉pantoprazole至少有效雷尼替丁在预防溃疡出血内镜止血法。口服或静脉注射pantoprazole高达240毫克/天维护目标酸产量水平在大多数患者hypersecretory条件,包括卓——艾氏综合症。口服给药和静脉注射pantoprazole似乎容忍acid-related障碍患者在短期和长期试验。 Tolerability with oral pantoprazole was similar to that with other PPIs or histamine H(2)-antagonists in short-term trials. Formal drug interaction studies have not revealed any clinically significant interactions between pantoprazole and other agents. In conclusion, pantoprazole is an effective agent in the management of acid-related disorders. As a component of triple therapy for H. pylori eradication and as monotherapy for the healing of oesophagitis and maintenance of GORD, pantoprazole has shown similar efficacy to other PPIs and greater efficacy than histamine H(2)-antagonists. Limited data suggest that it is also effective in Zollinger-Ellison syndrome and in preventing ulcer rebleeding. Pantoprazole is well tolerated with minimal potential for drug interactions. The availability of pantoprazole as both oral and intravenous formulations provides flexibility when the oral route of administration is not appropriate. Thus, pantoprazole is a valuable alternative to other PPIs in the treatment of acid-related disorders.

DrugBank数据引用了这篇文章

药物靶点

药物	目标	类	生物	药理作用	行动
Pantoprazole	Potassium-transporting atp酶α链1	蛋白质	人类	是的	抑制剂	细节