疗效和安全性的吸入比托特罗通过metered-dose甲磺酸在儿童哮喘吸入器。
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次数连续波,坎普JP,内森RA
疗效和安全性的吸入比托特罗通过metered-dose甲磺酸在儿童哮喘吸入器。
安过敏哮喘Immunol。1996年1月,76 (1):27-35。
- PubMed ID
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8564625 (在PubMed]
- 文摘
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背景:已经有许多研究在成人哮喘的疗效和安全性比托特罗甲磺酸metered-dose吸入器;然而,只有一个额外的研究检验了比托特罗metered-dose小儿哮喘吸入器。目的:建立的安全性和有效性比托特罗甲磺酸metered-dose吸入器一个,两个,三个吸气小儿哮喘病人4到12岁。方法:多中心、双盲、随机、交叉、安慰剂对照,dose-ranging研究。46例患者评估在三个中心。患者按年龄分层、4 - 6、7 - 9日在每个中心10到12年。一个,两个,三个吸气管理以及额外的双盲,随机,安慰剂剂量。Bronchodilation被定义为增加15%或更大的残在基线。发病、最大改进行动和持续时间为每个病人了。串行脉搏、血压和呼吸速率决定了每一个病人。 RESULTS: Onset within five minutes occurred in 56.6% to 71% of patients, depending on the dose. Mean maximum improvement, which was dose dependent, overall ranged from 28.2% to 40.3% with a peak response in 66.7 to 69.8 minutes. In direct relationship of magnitude with regard to dose of bitolterol was observed, (P < .001). A significant correlation, r = .732, in response between bronchodilation and baseline FEV1 was observed (P < .001). Median duration of action ranged from three to four hours in responding patients across all doses. Up to 31% of patients had durations greater than eight hours after three inhalations. Adverse effects were reported in five of 46 patients for all doses with mild transient tremor occurring in two patients, 4.3%. Also, there was little effect on pulse rate, 2.2%. CONCLUSION: Bitolterol is an effective bronchodilator with durations of activity up to eight hours and minimal adverse effects in children.
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