抗胆碱酯酶的影响的延迟动作电位在小鼠骨骼肌。

文章的细节

引用

复制到剪贴板

凯利党卫军渡轮CB, Bamforth JP

抗胆碱酯酶的影响的延迟动作电位在小鼠骨骼肌。

Br J杂志。1990年4月,99 (4):721 - 6。

PubMed ID

2361169 (在PubMed

]

文摘

1。这个调查的目的是确定的长期影响持久抗胆碱酯酶的单剂量肌肉动作电位诱发神经刺激。2。动作电位(ap),引起的刺激膈神经,记录细胞在老鼠的肌肉纤维隔膜。刺激和美联社之间的时间测量的可变性在火车的APs延迟计算。火车初APs的延迟增加,这延迟也测量。3所示。3小时内的皮下注射,一剂抗胆碱酯酶(500 nmol公斤),ecothiopate产生约90%的乙酰胆碱酯酶活性降低鼠标隔膜肌匀浆,但注射后5天,这个活动不是在未经处理的动物不同的值。APs的初始延迟和延迟的变化分别增加四倍和两倍,仍在这些极大值从1日到5日天ecothiopate后,在未经处理的动物和返回值ecothiopate后15至27天。4所示。 These effects of ecothiopate on AP latency were dose-dependent and were also seen in extensor digitorum longus and soleus muscles. 5. Other anticholinesterases used were BOS (pinacolyl S-(2-trimethylaminoethyl)methylphosphonothioate), a quaternary compound, and diisopropyl fluorophosphate, a tertiary compound, which had effects similar to those of ecothiopate; the greater duration of the effects of this compound may be related to the greater duration of reduction in cholinesterase activity. 6. Ecothiopate had no effect on the delay or variability of latencies of endplate potentials which were recorded in cut-fibre preparations 5 days later. 7. It is concluded that the effects of ecothiopate on the latencies of indirectly-evoked muscle APs are postjunctional, may not be related to the degree of reduction in cholinesterase activity at the time of recording, and are not directly linked to necrosis.

DrugBank数据引用了这篇文章

药物靶点

药物	目标	类	生物	药理作用	行动
Isoflurophate	胆碱酯酶	蛋白质	人类	是的	抑制剂	细节

药物酶

药物	酶	类	生物	药理作用	行动
Isoflurophate	胆碱酯酶	蛋白质	人类	未知的	抑制剂	细节