hexafluorenium交互与人血浆胆碱酯酶与六甲铵相比。

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hexafluorenium交互与人血浆胆碱酯酶与六甲铵相比。

Naunyn Schmiedebergs拱杂志。1976;293(1):由。

PubMed ID

948350年(在PubMed

]

文摘

1。化合物2的影响alkane-bis-onium hexafluorenium (HF1)和六甲铵(C6)在人血浆胆碱酯酶(ChE)研究了对抑制的类型。2。格瓦拉HF1和C6是可逆的抑制剂。的抑制效力HF1 (pI50 = 6.96;Ki = 2.4 x 10(9))大约是40 000倍高于C6 (pI50 = 2.4;Ki = 6.7 x 10 (2))。3所示。动力学分析显示竞争(C6)和非竞争性(hf1)的作用机制。4所示。 The inhibition of ChE by C6 is induced by a binding of C6 to the anionic site of the active center thus impairing the primary formation of the enzyme-substrate complex. HF1, however, is most probably bound to anionic side receptors in the vicinity of the active center; by that a conformational change of the enzyme protein is induced impairing the acylation step of the esteratic site.

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药物靶点

药物	目标	类	生物	药理作用	行动
Hexafluronium	胆碱酯酶	蛋白质	人类	是的	抑制剂	细节