孕产妇硫酸镁治疗对新生儿的影响:一个前瞻性对照研究。

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Riaz M,波拉特R,布罗斯基问,H

孕产妇硫酸镁治疗对新生儿的影响:一个前瞻性对照研究。

J Perinatol。1998; 11 - 12月18 (6 Pt (1): 449 - 54。

PubMed ID

9848759 (在PubMed

]

文摘

摘要目的:探讨孕产妇硫酸镁治疗新生儿的影响结果。方法:受试者新生婴儿>交货或= 34周妊娠的母亲收到了至少12小时静脉MgSO4疗法之前交付。控制下一个婴儿出生婴儿的胎龄相似。结果记录在交付包括阿普加分数,复苏是否需要,以及呼吸是否抑郁或降低音调被医生参加指出。Pneumocardiograms magnesium-exposed和控制婴儿,获得在6到18个小时交付后,分析了出院后由一个侦探被蒙蔽。幼儿园课程、喂养模式,第一个凳子,和第一个空白记录时间。所有患者的治疗决策,包括进入新生儿重症监护室(NICU)或托儿所,独立的研究协议。结果:26 magnesium-exposed和26控制婴儿了。交货前的平均总剂量MgSO4是51.2 + / -24通用;治疗的平均持续时间为23.1 + / -10小时。 The mean maternal serum magnesium level before delivery was 5.8+/-1.1 mg/dl. The infants' mean cord or initial serum magnesium level was 5.2+/-1.0 mg/dl, which correlated with the maternal magnesium level before delivery (r=0.81, p < 0.001). MgSO4-exposed infants had a higher incidence of hypotonia and lower median Apgar scores than control infants (p < 0.001). However, there was no association between adverse outcomes and maternal serum magnesium concentrations at delivery, duration of treatment, or dose of MgSO4. No difference in dose or length of maternal MgSO4 treatment was noted between infants admitted to term nursery and those admitted to NICU. Pneumocardiogram data were similar between MgSO4-exposed and control infants (all p > or = 0.16). There were no significant differences in number of episodes of feeding intolerance or in time to first stool or void between MgSO4-exposed and control infants (all p > or = 0.31). CONCLUSION: Infants born to mothers treated with MgSO4 were more likely to be hypotonic and have lower Apgar scores at birth. Beyond the immediate postdelivery period, there were no additional complications in this cohort attributable to prenatal MgSO4 exposure. We suggest that pediatricians attend deliveries of magnesium-exposed infants.

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硫酸镁