alanyl-glutamine临床安全的影响,氮平衡,肠道渗透性,和临床结果术后患者:一项随机、双盲、对照研究120例。

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ZM评选,曹JD,朱镕基XG,赵,JC,马埃尔,王XR,朱MW,蜀H,刘YW

alanyl-glutamine临床安全的影响,氮平衡,肠道渗透性,和临床结果术后患者:一项随机、双盲、对照研究120例。

JPEN J父肠内减轻。1999;9月- 10月23 (5):S62-6。

PubMed ID

10483898 (在PubMed

]

文摘

目的:评价的影响alanyl-glutamine (Ala-Gln)补充肠外营养(PN)对临床安全、氮平衡,肠道通透性,术后患者的临床结果。方法:一百二十例患者接受腹部手术主要是登记。协议获得批准和知情同意。一个双盲的协议被设计为在欧洲使用。的临床安全性和结果观察60例2中心(30)。每60病人从2额外的中心(30)观察临床安全、氮平衡,肠道通透性和临床结果。所有患者接受isonitrogenous(0.20克/公斤的身体每天wt)和等热量的(30千卡/公斤的身体每天wt)肠外营养。研究小组收到Ala-Gln (Dipeptiven费森尤斯公司Kabi,坏Homberg,德国)每天0.50克/公斤。临床化学变量,血浆氨基酸概要、氮平衡,肠道通透性(乳果糖/甘露醇比(L / M比值))测定;住院和感染率监控。 Statview was used for analysis of variance (ANOVA) or chi2 tests. Data were expressed as means +/- SD, and the significance level was p < .05. RESULTS: The patients in both groups were comparable prior to the operation. Vital signs and clinical chemical parameters were similar between groups. L/M ratio was 0.047+/-0.029 in control and 0.058+/-0.049 in study group before the operation (AOD-3). The L/M ratio was 0.132+/-0.081 in the control group, and 0.097+/-0.063 in study group on the seventh postoperative day. The difference of L/M ratio between groups was significant (p = .02). The cumulative nitrogen balance values were -5+/-162 mg/kg for 6 days in control and 144+/-145 mg/kg for 6 days in study group (p = .0004). All the patients recovered without incision infection. However, there were 3 cases that had infection-related complications in the control group; the difference was not significant between groups. The hospital stay in the study group was 12.5 days, which was 4 days less than that of the control group (p = .02). CONCLUSIONS: Ala-Gln-supplemented PN was clinically safe, had better nitrogen balance, and maintained intestinal permeability in postoperative patients. The clinical outcome of the patients in study group was better; it was significantly different from the control group.

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