系统性的影响注射维拉佐酮,一种选择性5 -羟色胺再摄取抑制剂1和5 -羟色胺受体激动剂,在大鼠焦虑捕食者引起的压力。
文章的细节
-
引用
复制到剪贴板 -
Adamec R, Bartoszyk GD,伯顿P
系统性的影响注射维拉佐酮,一种选择性5 -羟色胺再摄取抑制剂1和5 -羟色胺受体激动剂,在大鼠焦虑捕食者引起的压力。
欧元J杂志。2004年11月3日,504 (2):65 - 77。
- PubMed ID
-
15507223 (在PubMed]
- 文摘
-
我们检查了维拉佐酮的影响,选择性5 -羟色胺再摄取抑制剂(SSRI) 1和5 -羟色胺(5 - (1 a)受体激动剂(Bartoszyk,国民生产总值Hegenbart, R。齐格勒,H。,1997年。68843年EMD和选择性5 -羟色胺再摄取抑制剂突触前5-HT1A受体论争的属性。欧元。j .杂志。322年,147 - 153。], on change in affect following predator stress. Vilazodone and vehicle injection (intraperitoneal) occurred either 10 min after predator stress (prophylactic testing), or 90 min prior to behavioral testing for the effects of predator stress (therapeutic testing). Predator stress involved unprotected exposure of rats to a domestic cat. Behavioral effects of stress were evaluated with hole board, plus-maze, and acoustic startle tests 1 week after stress. Predator stress increased anxiety-like behavior in the plus-maze and elevated response to acoustic startle. In prophylactic testing, Vilazodone affected stress potentiation of startle at doses above 5 mg/kg. Vilazodone increased stress elevation of startle at 10 mg/kg. Higher doses of Vilazodone (20 and 40 mg/kg) blocked stress potentiation of startle. In contrast, Vilazodone had no effect on stress potentiation of anxiety in the plus-maze. In therapeutic testing, Vilazodone increased stress elevation of startle at all doses. In contrast, therapeutic Vilazodone had no effect on stress potentiation of anxiety in the plus-maze. Taken together, the data suggest a prophylactic potential for Vilazodone in the treatment of changes in hypervigilance following severe stress.