外用阿普劳尼定对LASIK患者结膜下出血和皮瓣粘连的影响。
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Aslanides lM, Tsiklis NS, Ozkilic E, Coskunseven E, Pallikaris lG, Jankov MR
外用阿普劳尼定对LASIK患者结膜下出血和皮瓣粘连的影响。
折射外科杂志，2006;22(6):585-8。
- PubMed ID
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16805122 (PubMed视图］
- 摘要
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目的:确定LASIK手术前外用阿普劳尼定是否能预防结膜下出血，并研究其对术后皮瓣粘附的影响。方法:66例初次双侧LASIK近视患者1眼随机外用阿普罗柯尼定0.125%。在放置微型角膜刀真空环前1小时30秒灌注阿普拉可尼定，另一只眼作为对照。手术后30分钟，外科医生对所有患者进行检查，以评估充血情况并确定皮瓣相关并发症(如滑脱、脱位或皮瓣褶皱)。术后第1天和第7天也评估结膜下出血的大小。研究中所有132只眼睛在手术后都接受了检查，以确定皮瓣褶皱和/或脱位。结果:阿帕可尼定组48只(72.8%)眼无充血，16只(24.2%)眼轻度充血，2只(3%)眼中度充血，无(0%)眼重度充血。对照组轻度充血37只(56.1%)眼，中度充血21只(31.8%)眼，重度充血1只(1.5%)眼，无充血7只(10.6%)眼。阿匹可尼定组44只(66.7%)眼无结膜下出血(0级);1级有19只(28.8%)眼，2级和3级分别有2只(3%)眼和1只(1.5%)眼。 In the control group, 19 (28.8%) eyes showed grade 0, 13 (19.7%) eyes had grade 1, and grades 2 and 3 were present in 20 (30.3%) eyes and 14 (21.2%) eyes, respectively. Chi-square test showed a highly significant difference between the two groups (P < .001). No flap-related problems were reported in either group. CONCLUSIONS: Topical apraclonidine applied before LASIK surgery may prevent immediate postoperative hyperemia and prolonged subconjunctival hemorrhage by its alpha-mimetic vasoconstrictor effect without inducing flap adherence complication.
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