Pim-3异常表达参与胃腺瘤-腺癌序列和癌症进展。
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郑hc, Tsuneyama K，高桥H, Miwa S, Sugiyama T, Popivanova BK，藤井C，野本K, Mukaida N，高野Y
Pim-3异常表达参与胃腺瘤-腺癌序列和癌症进展。
中华肿瘤学杂志，2008年4月;34(4):481-8。Epub 2007 9月18日。
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17876606 (PubMed视图］
- 摘要
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目的:具有丝氨酸/苏氨酸激酶活性的原癌基因Pim家族成员Pim-3在肝、胰腺和结肠等内胚层来源器官的癌变中异常表达。本研究旨在阐明Pim-3表达在胃癌发生和发展中的作用。方法:在胃癌原发(n = 285)和转移(n = 37)部位的组织微阵列上免疫组化检测Pim-3的表达，并与腺瘤(n = 48)和非癌黏膜(n = 84)进行比较。并与胃癌的临床病理参数进行了比较。结果:Pim-3在胃癌腺瘤(64.6%)和转移部位(73.0%)表达上调，在胃癌原发部位(39.3%)表达低于非癌黏膜(13.1%，p < 0.0001)。肠型胃癌中Pim-3的表达水平高于扩散型胃癌(p = 0.018)。Pim-3表达与性别(p = 0.047)、淋巴(p = 0.019)和静脉侵犯(p = 0.014)密切相关。Pim-3的表达与血管内皮生长因子(VEGF, p = 0.009)和细胞外基质金属蛋白酶诱导因子(EMMPRIN, p = 0.032)显著相关，这两种因子均可能参与转移的关键步骤新生血管。相反，人10号染色体(Pten)阴性胃癌中缺失的磷酸酶和紧张素同源蛋白表达水平高于Pten阳性胃癌(p = 0.042)。胃癌组织中Pim-3表达与MVD无相关性(p = 0.715)。 Furthermore, patients with Pim-3 positive gastric cancer, showed a lower cumulative survival rate than those with Pim-3 negative gastric cancer (p = 0.014) and Pim-3 positive was also identified as an independent prognostic factor for gastric carcinoma patients (p = 0.006). CONCLUSIONS: Aberrant Pim-3 expression was involved in gastric adenoma-adenocarcinoma sequence and subsequent invasion and metastasis process in gastric cancer. Moreover, Pim-3 may be employed to predict the prognosis of gastric cancer patients. Distinct Pim-3 expression underlies the molecular mechanisms for the differentiation of intestinal-type and diffuse-type carcinomas.