功能描述人类受体的短链脂肪酸和多形核细胞的激活作用。
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Le Poul E, Loison C, Struyf年代,Springael司法院,Lannoy V, Decobecq我,Brezillon年代,Dupriez V, Vassart G, Van Damme J,有土豆的M, Detheux M
功能描述人类受体的短链脂肪酸和多形核细胞的激活作用。
生物化学杂志。2003年7月11日;278 (28):25481 - 9。Epub 2003年4月23日。
- PubMed ID
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12711604 (在PubMed]
- 文摘
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短链脂肪酸(SCFAs),包括乙酸,丙酸,丁酸,产生高浓度由细菌在肠道,随后在血液中释放。血液中基醋酸浓度(约100 microm)可以进一步提高毫克分子浓度酒精摄入量。以前是知道SCFAs可以激活白细胞,尤其是中性粒细胞。在目前的工作,我们之前已经确定了两个孤儿G protein-coupled受体,GPR41 GPR43,作为SCFAs受体。丙酸是最强有力的兴奋剂GPR41和GPR43。醋酸是GPR43更有选择性,而丁酸和异丁酸盐在GPR41更加活跃。这两个受体是耦合的肌醇1,4,5-trisphosphate形成,细胞内钙离子释放,ERK1/2激活和抑制阵营积累。然而,他们表现出一个微分G蛋白耦合;GPR41耦合只虽然百日咳toxin-sensitive Gi / o家庭,而GPR43显示双耦合通过Gi / o和百日咳toxin-insensitive Gq蛋白质家族。GPR41的广泛表达谱的组织不允许我们推断出明确的假设关于其生物功能。 In contrast, the highly selective expression of GPR43 in leukocytes, particularly polymorphonuclear cells, suggests a role in the recruitment of these cell populations toward sites of bacterial infection. The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis. Such a neutrophil-specific SCFA receptor is potentially involved in the development of a variety of diseases characterized by either excessive or inefficient neutrophil recruitment and activation, such as inflammatory bowel diseases or alcoholism-associated immune depression. GPR43 might therefore constitute a target allowing us to modulate immune responses in these pathological situations.