Amlexanox治疗复发性口腔溃疡。

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贝尔J

Amlexanox治疗复发性口腔溃疡。

中国药物Investig。2005; 25 (9): 555 - 66。

PubMed ID

17532700 (在PubMed

]

文摘

复发性口腔溃疡(RAU)是最常见的口腔粘膜疾病在人类中,估计影响5%至50%的普通人群。的小表现情况是最常见的特点是小,浅,圆形或椭圆形病变引起红斑的光环包围着,左边是由灰白。适当的管理患者的这种情况在很大程度上是和应该关注减少溃疡症状持续时间、缓解疼痛,减少或防止溃疡复发。Amlexanox是一种新型的抗炎和抗过敏剂,评估治疗劳在一系列强劲的临床试验。100毫克剂量的5%后amlexanox局部粘贴,直接用于病变,药物的最大血清浓度是120 ng / mL,应用后取得了2.4小时。稳态浓度达到1周内开始四次每日剂量和没有积累的证据。在疗效方面,应用5% amlexanox局部粘贴了持续和显著加速完成溃疡愈合,疼痛的时间分辨率在四大功效的研究。更多患者完全愈合溃疡从第三天(而没有治疗)和第四天(与汽车相比)。治疗被疼痛的改善:反映更多的患者从第二天疼痛完全消失(与之相比没有治疗),第三天(与汽车相比)。总的来说,amlexanox耐受性良好,低频率的不利影响。 In the oral application studies, adverse effects that were considered by investigators to be potentially related to the study treatment occurred in 2.4% and 2.1% of 5% amlexanox and vehicle recipients, respectively. These effects were mainly local and were all classed as mild to moderate in severity, with the exception of one case of severe stinging in the vehicle treatment group. Furthermore, the incidence of dermal irritation and sensitisation was very low with amlexanox. These findings suggest that 5% amlexanox topical paste is a useful and well tolerated therapeutic option for the treatment of RAU.

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药物

Amlexanox