盘状红斑狼疮的药物。
文章的细节
-
引用
复制到剪贴板 -
Jessop年代,怀特劳D,乔达安F
盘状红斑狼疮的药物。
科克伦数据库系统启2001;(1):CD002954。
- PubMed ID
-
11279785 (在PubMed]
- 文摘
-
背景:盘状红斑狼疮是一种慢性的皮肤(皮肤)红斑狼疮能造成永久性疤痕如果治疗是不够的。许多药物已经用于治疗这种疾病,其中的一些可能是非常有毒。目的:评估盘状红斑狼疮药物的影响。必威国际app搜索策略:我们搜查了Cochrane临床试验注册(1999年12月),MEDLINE(1966年1月至1999年12月)、EMBASE(1980年1月至2000年1月),和引用列表相关的评论。指数Medicus(1956 - 1966)是handsearched和7必威国际app该领域的专家在与信息未发表的试验。选择标准:随机试验的药物来治疗盘状红斑狼疮患者。药物包括在搜索是咪唑硫嘌呤、氯喹、氯法齐明,必威国际app皮质类固醇,(口服和局部)、氨苯砜、黄金、干扰素alpha-2a,甲氨蝶呤、苯妥英、类维生素a, sulphasalazine萨力多胺。数据收集和分析:两个评论者独立检查每个检索研究资格。主要结果:两个试验包括136名参与者。12周时间的交叉研究氟轻松醋酸酯0.05%奶油(一种有效的局部皮质类固醇),似乎是明显优于氢化可的松1%奶油(温和的类固醇)。 Clearing or excellent improvement was seen in 27% of people using fluocinonide and in 10% of those using hydrocortisone, giving a 17% absolute benefit in favour of fluocinonide (95% CI 4.5 to 29.5% and NNT 6). In the second trial, hydroxychloroquine was compared with acitretin in 58 people. There was marked improvement or clearing in 46% of people using acitretin and in 50% of those on hydroxychloroquine, a nonsignificant 4% absolute gain with hydroxychloroquine (95%CI -23% to 30%). The adverse effects were more frequent and more severe in the acitretin group. REVIEWER'S CONCLUSIONS: Fluocinonide cream may be more effective than hydrocortisone in treating people with discoid lupus erythematosus. Hydroxychloroquine and acitretin appear to be of equal efficacy, although adverse effects are more frequent and more severe with acitretin. There is not enough reliable evidence about other drugs used to treat discoid lupus erythematosus.