比较静脉注射右旋糖酐铁管理局后氧化应激标志物,葡萄糖酸钠铁和铁蔗糖在接受血液透析的患者。

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Pai AB,博伊德AV, McQuade CR,哈福德,Norenberg JP,急变PG

比较静脉注射右旋糖酐铁管理局后氧化应激标志物,葡萄糖酸钠铁和铁蔗糖在接受血液透析的患者。

药物治疗。2007年3月,27 (3):343 - 50。

PubMed ID

17316146 (在PubMed

]

文摘

研究目的:比较non-transferrin-bound铁和氧化应激的标记单剂量静脉注射右旋糖酐铁后,葡萄糖酸钠铁,铁蔗糖。设计:前瞻性、非盲、交叉研究。背景:大学附属一般临床研究中心。必威国际app病人:十二步接受血液透析的患者。干预:患者接受100毫克的静脉注射右旋糖酐铁、葡萄糖酸钠铁,在随机序列和铁蔗糖,之间的洗脱期2周治疗。测量及主要结果:血清样本转铁蛋白饱和度,non-transferrin-bound铁,和丙二醛(MDA);脂质过氧化的标志)是获得前(基线)和30岁,60岁,120年,每360分钟和2周后铁注入。血清样本hemeoxygenase-1 (HO-1) RNA注入后得到在基线和360分钟。Non-transferrin-bound铁值明显高于30分钟后政府的葡萄糖酸钠铁和铁蔗糖与铁右旋糖酐(意思是+ / - SEM 10.1 + / - 2.2, 3.8 + / - 0.8,和0.23 + / - -0.1 microM分别p < 0.001葡萄糖酸钠铁vs右旋糖酐铁,铁铁右旋糖酐蔗糖与p = 0.002)。之间显著正相关是指出转铁蛋白饱和度和non-transferrin-bound铁的存在对葡萄糖酸钠铁和铁蔗糖(r2 = 0.37和0.45,分别p < 0.001),但不是为右旋糖酐铁(r2 = 0.09)。 After sodium ferric gluconate, significantly more samples showed increases in MDA levels from baseline compared with iron sucrose and iron dextran (p = 0.006); these increased levels were associated with the presence of non-transferrin-bound iron, baseline transferrin saturation above 30%, baseline transferrin levels below 180 mg/dl, and ferritin levels above 500 ng/ml (p<0.05). However, only a transferrin level below 180 mg/dl was independently associated (odds ratio 4.8, 95% confidence interval 1.2-15.3). CONCLUSION: Iron sucrose and sodium ferric gluconate were associated with greater non-transferrin-bound iron appearance compared with iron dextran. However, only sodium ferric gluconate showed significant increases in lipid peroxidation. The relationship between non-transferrin-bound iron from intravenous iron and oxidative stress warrants further exploration.

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药物载体

药物	航空公司	类	生物	药理作用	行动
右旋糖酐铁	Serotransferrin	蛋白质	人类	未知的	底物	细节