抗氧化的影响β受体阻滞剂塞在高血压大鼠内皮祖细胞。

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姚明呃,福田N,松本T, Katakawa M,山本C,汉族Y,上野T,小林N,松本K

抗氧化的影响β受体阻滞剂塞在高血压大鼠内皮祖细胞。

J Hypertens。2008年9月,21 (9):1062 - 8。doi: 10.1038 / ajh.2008.233。Epub 2008年7月17日。

PubMed ID

18636069 (在PubMed

]

文摘

背景:内皮祖细胞(epc)来源于骨髓移植内皮损伤和修复它们。EPC氧化应激功能受损。我们检查了一个抗氧化的影响beta1-adrenoceptor拦截器在高血压大鼠内皮祖细胞的数量和功能。方法:自发性高血压大鼠(月)和Wistar-Kyoto (WKY)含有高盐食物喂养的老鼠。这个月塞或阿替洛尔治疗,疗程2周。外周血单核细胞(跨国公司)分离,进行流量仪分析来确定循环内皮祖细胞的数量,和培养量化EPC集落形成。EPC迁移评估在迁移试验腔。分析EPC衰老评估使用β-半乳糖。内皮祖细胞的氧化应激评估使用硫代巴比土acid-reactive物质(TBARS)测定。的表达nicotinamine腺嘌呤二核苷酸磷酸氧化酶(NAD (P) H)组件mrna在肾皮质,主动脉,心脏被实时PCR评估。 RESULTS: The number, colony formation, and migration of EPCs in SHRs were significantly lower than those in WKY rats. TBARS scores in EPCs from SHRs were significantly higher than those from WKY rats. Celiprolol increased the number of circulating EPCs and stimulated EPC colony formation and migration, while decreasing EPC senescence. Celiprolol inhibited oxidation in EPCs from SHRs, and decreased the expression of NAD(P)H oxidase component mRNAs in the renal cortex, aorta, and heart. CONCLUSION: EPCs are impaired in SHRs in response to oxidative stress. Celiprolol decreases oxidative stress in hypertension in vivo and improves EPC numbers and function. It appears, therefore, that celiprolol may exert beneficial cardiovascular effects through its antioxidative properties.

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药物靶点

药物	目标	类	生物	药理作用	行动
塞	beta 1肾上腺素能受体	蛋白质	人类	是的	拮抗剂	细节