回顾行动的潜在机制巴氯芬的酒精使用障碍。

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de Beaurepaire R

回顾行动的潜在机制巴氯芬的酒精使用障碍。

精神病学。2018年10月17日,9:506。doi: 10.3389 / fpsyt.2018.00506。eCollection 2018。

PubMed ID

30459646 (在PubMed

]

文摘

巴氯芬,GABA-B受体受体激动剂,是一种有前途的治疗酒精使用障碍(AUD)。在这种情况下它的作用机制是未知的。GABA-B受体与许多生物系统可能涉及在澳大利亚,包括转导通路和神经递质系统。临床前研究表明,GABA-B受体参与记忆存储和检索、奖励、动机、情绪和焦虑;人类神经影像学研究表明,巴氯芬生产区域改变大脑活动;GABA-B受体激活可能有神经保护作用;巴氯芬也有抗炎作用,可能感兴趣的上下文中的成瘾。然而,这些生物效应完全解释澳元的巴氯芬的作用机制。临床研究的数据提供了一定数量的元素可能是有用的理解其作用机理:巴氯芬通常对酒精诱发漠不关心的状态;巴氯芬的有效剂量,澳大利亚是非常变量从一个病人到另一个; higher treatment doses correlate with the severity of the addiction; many of the side effects of baclofen resemble those of alcohol, raising the possibility that baclofen acts as a substitution drug; usually, however, there is no tolerance to the effects of baclofen during long-term AUD treatment. In the present article, the biological effects of baclofen are reviewed in the light of its clinical effects in AUD, assuming that, in many instances, clinical effects can be reliable indicators of underlying biological processes. In conclusion, it is proposed that baclofen may suppress the Pavlovian association between cues and rewards through an action in a critical part of the dopaminergic network (the amygdala), thereby normalizing the functional connectivity in the reward network. It is also proposed that this action of baclofen is made possible by the fact that baclofen and alcohol act on similar brain systems in certain regions of the brain.

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药物

巴氯芬

药物靶点

药物	目标	类	生物	药理作用	行动
巴氯芬	C-X-C趋化因子受体类型4	蛋白质	人类	未知的	变构调制器	细节