荟萃分析的有效性和安全性的pantoprazole治疗和患者症状缓解胃食管返流疾病——PAN-STAR。

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Dabrowski A、B Stabuc Lazebnik L

荟萃分析的有效性和安全性的pantoprazole治疗和患者症状缓解胃食管返流疾病——PAN-STAR。

Prz杂志。2018;13 (1):6 - 15。doi: 10.5114 / pg.2018.74556。Epub 2018年3月26日。

PubMed ID

29657605 (在PubMed

]

文摘

简介:质子泵抑制剂疗法成功治疗胃食管反流病(GERD)是一个艰巨的任务,因为粘膜损害的程度与症状的严重程度没有关系。目的:建立pantoprazole治疗的疗效腐蚀性返流性疾病患者(ERD)和那些non-erosive返流性疾病(书呆子),通过评估症状和生活质量。治疗持续时间和pantoprazole治疗相关的不良事件进行分析。材料和方法:本荟萃分析是基于三个多中心,前瞻性,非盲、IV期临床试验在斯洛文尼亚,波兰和俄罗斯联邦。总共252 GERD患者包括对待pantoprazole 40毫克每天4或8周后,根据实现预定义的治疗标准。症状病人的评估等级从0到3和生活质量评定量表从1到10。结果:百分之四十五的患者达到康复标准治疗4周后,治疗8周后,70%的患者。病人未能达到治愈标准报告显著减少症状的严重性。响应8周治疗患者明显高于ERD(76%)相比,书呆子的患者(64%)。停止治疗后4周与症状恶化无关,不影响生活质量。 Pantoprazole treatment was associated with improvement of symptoms and the quality of life of GERD patients over 8 weeks of treatment and showed that GERD patients with persisting symptoms benefit from prolonging treatment to 8 weeks. Treatment with pantoprazole 40 mg was very well tolerated - more than 90% of patients were without adverse events throughout the whole study and only 4 patients discontinued the treatment due to adverse events related to pantoprazole treatment. Conclusions: Pantoprazole 40 mg was associated with complete relief of GERD-related symptoms in the majority of patients with ERD and NERD. Furthermore, the severity of symptoms was significantly reduced in patients without complete relief of symptoms. Pantoprazole also continuously improved the quality of life of GERD patients over 8 weeks of treatment and was very well tolerated throughout the whole study. Therefore, this meta-analysis suggests that pantoprazole 40 mg once daily is an effective and well-tolerated choice for providing symptom relief of patients with GERD.

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药物

Pantoprazole