大剂量奥美拉唑联合阿莫西林和阿奇霉素根除十二指肠溃疡幽门螺杆菌。

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Vcev A, Stimac D, Vceva A, Takac B, Pezerovic D, Ivandic A

大剂量奥美拉唑联合阿莫西林和阿奇霉素根除十二指肠溃疡幽门螺杆菌。

幽门螺杆菌。1999;4(1):54-7。

PubMed ID

10352088 (PubMed视图

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摘要

背景:我们研究的目的是确定低剂量(2 × 20mg /天)或高剂量(2 × 40mg /天)的一周三联治疗方案(奥美拉唑、阿莫西林、阿奇霉素)是否更有效地治疗活动性十二指肠溃疡患者的幽门螺杆菌感染。方法:120例十二指肠溃疡合并幽门螺旋杆菌感染患者在治疗前7 d采用阿莫西林2 × 1000 mg/d +阿奇霉素500 mg/d治疗前6 d。患者被随机分配在前7天接受奥美拉唑2 x 20mg /天(A组;n = 60)或奥美拉唑2 x 40 mg/天，前7天(B组;N = 60)。7天后，两组患者均继续服用奥美拉唑(40mg /天(8-14天)和20mg /天(15-28天))。治疗前和停药后4周分别通过脲酶试验和组织学检查幽门螺杆菌状态。结果:113例患者完成了研究。A组患者幽门螺杆菌感染根除率为73.2%[41/56](意向治疗分析:68.3%;95% CI: 58.6-80.4%) vs. 82.5% [47/57] (ITT分析:78.3%; 95% CI: 67.8-87.9%; NS). All ulcers had healed after 4 weeks of omeprazole treatment. Side effects, usually minor, were recorded in 12.5% (group A) and in 14% (group B) of patients (NS), but therapy was discontinued for only one patient in group B (NS). CONCLUSION: There was no statistically significant difference between one-week triple therapy regimen (omeprazole, amoxicillin, azithromycin) with high dose omeprazole (2 x 40 mg/day) and regimen with low dose omeprazole (2 x 20 mg/day) in curing H. pylori infection in patients with active duodenal ulcer disease.

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