互动和延迟的影响吡斯的明和物理压力对生化和组织学的变化外围组织的老鼠。
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Somani SM,侯赛因K, T亚莎,Helfert R
互动和延迟的影响吡斯的明和物理压力对生化和组织学的变化外围组织的老鼠。
J: Toxicol。2000 Jul-Aug; 20 (4): 327 - 34。
- PubMed ID
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10942908 (在PubMed]
- 文摘
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海湾战争退伍军人口服吡斯的明对可能接触神经毒气以及在身体压力。本研究旨在探讨延迟吡斯的明和跑步机锻炼对胆碱酯酶活性的影响,脂质过氧化反应和组织学的外围组织的老鼠。瑞士男性NIH小鼠分成四组15动物每治疗如下:久坐不动的控制;运动训练10周;吡斯的明(1.2毫克公斤(1),订单)2周在第5和6周;和吡斯的明+运动训练。老鼠牺牲24 h后锻炼,和血液,三头肌肌肉和坐骨神经分离和分析。吡斯的明单独显示治疗组降低等离子体butyrylcholinesterase (BChE)活动(控制)的87%,而吡斯的明+运动显著降低BChE活动(控制)的79%,表明一个互动效应的组合。乙酰胆碱酯酶(疼痛)活动没有显著改变红细胞,血小板或坐骨神经的治疗。然而,肱三头肌肌肉疼痛活动显著降低(控制)的78%吡斯的明+运动治疗组。 Creatine phosphokinase activity in plasma increased slightly (compared to control, pyridostigmine or exercise group) in mice treated with pyridostigmine plus exercise, which may be indicative of perturbation in the integrity of the skeletal muscle due to combination. However, there were no obvious histological abnormalities in the triceps muscle detected between experimental and control groups. Interaction of pyridostigmine and exercise significantly increased the concentration of the end product of lipid peroxidation (malondialdehyde) (124% of control) in triceps muscle, indicating an oxidative stress response of the combination. These results indicate that physical stress enhanced the delayed toxic effects of a subchronic oral dose of pyridostigmine primarily in the skeletal muscle of mice.