车前草优于docusate钠治疗慢性便秘。

文章的细节

引用

复制到剪贴板

McRorie JW, Daggy BP,莫雷尔詹,辽阔PS,矿工PB,罗宾逊M

车前草优于docusate钠治疗慢性便秘。

滋养品杂志。1998;12 (5):491 - 7。

PubMed ID

9663731 (在PubMed

]

文摘

背景:粪便软化是一个内科医生的慢性便秘的管理的第一步。目的:比较粪便软化粪便含水量和泻药的功效车前草亲水性mucilloid与docusate钠。方法:多站点,随机、双盲、parallel-design研究170例慢性特发性便秘了帷幕,基线(安慰剂)阶段治疗2周。车前草相比治疗阶段(5.1 g b.d。) + docusate安慰剂docusate钠(100毫克b.d。)加上车前草安慰剂。大便收集和评估。结果:与基线相比,车前草增加粪便含水量与docusate(车前草2.33%比docusate 0.01%, P = 0.007)。亚麻籽也增加了粪便水重量(车前草84.0 g / BM;docusate 71.4 g / BM;P = 0.04),凳子总产量(车前草359.9 g /周:docusate 271.9 g /周;P = 0.005), O ' brien阶式评分结合客观措施便秘(车前草475.1; docusate 403.9; P = 0.002). Bowel movement (BM) frequency was significantly greater for psyllium (3.5 BM/week) vs. docusate (2.9 BM/week) in treatment week 2 (P = 0.02), with no significant difference (P > 0.05) between treatment groups in treatment week 1 (3.3 vs. 3.1 BM/week). CONCLUSION: Psyllium is superior to docusate sodium for softening stools by increasing stool water content, and has greater overall laxative efficacy in subjects with chronic idiopathic constipation.

DrugBank数据引用了这篇文章

药物

Docusate