检测多虑平及其主要代谢物desmethyldoxepin药物治疗后的头发。
文章的细节
-
引用
复制到剪贴板 -
Negrusz,摩尔厘米,佩里杰
检测多虑平及其主要代谢物desmethyldoxepin药物治疗后的头发。
J肛门Toxicol。1998年10月,22 (6):531 - 6。
- PubMed ID
-
9788530 (在PubMed]
- 文摘
-
多虑平是一个三环抗抑郁药,治疗轻度抑郁的广泛的规定。在这项研究中,头发样本收集从一个病人接受25毫克的多虑平日常进行了分析。多虑平让病人服用了4个月(1996年6月15日至10月15日)。五个头发样本收集:1和多虑平治疗开始后3个月和1,3,5个月后药物治疗结束。固相萃取是用来隔离多虑平及其主要代谢物desmethyldoxepin头发的矩阵,以及气相色谱分析-质谱法(gc - ms)用于定量的药物。六点标准曲线(0.25 -20 ng /毫克)准备两个化合物与内部标准(doxepin-d3)。多虑平、desmethyldoxepin的标准曲线线性范围报告和相关系数为0.984和0.985,分别。极限的定量分析物是头发的0.25纳克/毫克。此外,复制控制头发准备在两个层面上进行分析(2 ng / mg和15 ng / mg)来确定内部和interday可变性。多虑平和desmethyldoxepin没有检测到在病人的样本收集多虑平治疗开始后1个月。 The samples collected 3 months after doxepin therapy began and 5 months after drug therapy was terminated had detectable amounts of doxepin and desmethyldoxepin. The highest concentrations of doxepin (mean, 0.59 ng/mg) and desmethyldoxepin (mean, 0.40 ng/mg) were found 5 months after doxepin therapy began, which was also 1 month after the patient had stopped using the drug. Five months after doxepin therapy was terminated, the drug and its metabolite were still present in the patient's hair. The concentration of doxepin in hair was always significantly higher than the concentration of desmethyldoxepin.
DrugBank数据引用了这篇文章
- 药物
- 药物反应
-
反应 细节
