临床药理学的吲哚美辛在早产儿动脉导管未闭关闭的影响。

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临床药理学的吲哚美辛在早产儿动脉导管未闭关闭的影响。

Paediatr药物。2013年10月,15 (5):363 - 76。doi: 10.1007 / s40272 - 013 - 0031 - 7。

PubMed ID

23754139 (在PubMed

]

文摘

吲哚美辛是一种非甾体抗炎药,是合成前列腺素E(2)的有效抑制剂。出生后,开放性动脉导管关闭2 - 4天内自发的婴儿。关闭开放性动脉导管的主要因素是氧气的张力,从而增加显著出生后。前列腺素E(2)氧气有相反的效果;可以放松平滑肌,倾向于抑制开放性动脉导管的关闭。在早产儿呼吸窘迫综合征,开放性动脉导管未关闭(动脉导管未闭(PDA)),因为前列腺素E2的浓度相对较高。PDA发生在超过70%的新生儿在出生时体重小于1500克。本文的目的是审查发布的数据在早产儿临床药理学的吲哚美辛为了提供一个关键的分析文学和医生的有用工具。书目搜索进行电子使用PubMed和E必威国际appMBASE数据库搜索引擎和2012年2月截止点。观察一个了不起的个人间变异性的半衰期(t((1/2)))间隙(CL)、分布和体积(V (d))的吲哚美辛。 Prophylactic indomethacin consists of a continuous infusion of low levels of indomethacin and may be useful in preterm infants. Extremely preterm infants are less likely to respond to indomethacin. Infants with a postnatal age of 2 months do not respond to treatment with indomethacin. Indomethacin has several adverse effects, the most common of which is renal failure. An increase in serum creatinine of >/=0.5 % mg/dL after indomethacin was observed in about 10-15 % of the patients and creatinine returns to a normal level about 1 week after cessation of therapy. Indomethacin should be administered intravenously by syringe pump for at least 30 min to minimize adverse effects on cerebral, gastrointestinal, and renal blood flow velocities. A prolonged course of indomethacin appears to reduce the risk of severe intracranial hemorrhage and renal impairment in patients with PDA. In conclusion, indomethacin is a useful drug to treat PDA.

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药物

吲哚美辛