帕罗西汀治疗早泄:系统回顾和荟萃分析。

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张东，程勇，吴坤，马强，蒋军，严志

帕罗西汀治疗早泄:系统回顾和荟萃分析。

生物医学工程学报，2019,1(1):2。doi: 10.1186 / s12894 - 018 - 0431 - 7。

PubMed ID

30606186 (PubMed视图

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摘要

背景:帕罗西汀是一种选择性血清素再摄取抑制剂(SSRIs)用于早泄(PE)的治疗。然而，这种用法在许多国家都不被批准。本系统综述和荟萃分析的目的是回顾帕罗西汀对PE患者的疗效和安全性。方法:我们使用PubMe必威国际appd、Embase和Cochrane Central Register检索截至2018年5月的相关随机对照试验。主要终点包括阴道内射精潜伏期(IELT)和PE治疗的副作用。采用Cochrane Collaboration的Revman 5.3版软件进行统计分析。结果:在493篇独特的文章中，共回顾了19项随机对照试验(RCTs)。由于信息有限，相当多的rct被认为具有不明确的偏倚风险。综合结果显示，帕罗西汀在提高雅思成绩方面比安慰剂、氟西汀和艾司西酞普兰更有效(p < 0.05)。然而，帕罗西汀组与氟西汀组以及帕罗西汀组与安慰剂组存在高度异质性。 Comparing paroxetine with tramadol, sertraline, phosphodiesterase 5 inhibitors (PDE5Is), local lidocaine gel, behaviour therapy or dapoxetine, we found that the increase in IELT was not statistically significant between groups. Paroxetine combined with tadalafil or behaviour therapy was more efficacious than paroxetine alone (all p < 0.05). Although the side effects in the combination group were more common than in the paroxetine alone group, the most common adverse events, such as nausea, muscle soreness, palpitation and flushing, were mild and tolerable. The main limitations of this systematic review and meta-analysis were the different definitions of PE and short follow-up times. CONCLUSIONS: According to this systematic review and meta-analysis, paroxetine provided better efficacy than placebo, fluoxetine and escitalopram in the treatment of PE, with well-tolerated side effects. The combination group had better efficacy than the paroxetine alone group. TRIAL REGISTRATION: This review was reported in agreement with the PRISMA statement and was registered on PROSPERO 2018CRD42018097014 .

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