有效性和安全性的系统评价不同方案的levonorgestrel口服紧急避孕药片。
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Shohel M,拉赫曼MM,扎曼,Uddin MM, Al-Amin MM, Reza嗯
有效性和安全性的系统评价不同方案的levonorgestrel口服紧急避孕药片。
BMC女性健康。2014年4月4日14:54。doi: 10.1186 / 1472-6874-14-54。
- PubMed ID
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24708837 (在PubMed]
- 文摘
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背景:意外怀孕是一个复杂的现象提出采取紧急的决定。避孕普及率低的主要原因是用户和高失败率这意想不到的情况。高用户紧急避孕的失败率建议至关重要的作用,以防止意外怀孕。Levonorgestrel——紧急避孕的常用黄体酮。然而,很少有人知道其药物动力学和最佳剂量使用。因此,有必要进行系统回顾可用的证据。方法:随机、双盲试验,评价健康女性正常月经周期,要求紧急避孕72 h内无保护的性交,三种方案:1.5毫克剂量levonorgestrel,两剂0.75毫克levonorgestrel 12 h分开或两个剂量的0.75毫克levonorgestrel隔24 h。主要结果是意外怀孕;其他结果是下次月经的副作用和时机。正在考虑的结果:每个试验成功建立的避孕有效性levonorgestrel防止意外怀孕。 Moreover, a single dose of levonorgestrel 1.5 mg for emergency contraception supports its safety and efficacy profile. If two doses of levonorgestrel 0.75 mg are intended for administration, the second dose can positively be taken 12-24 h after the first dose without compromising its contraceptive efficacy. The main side effect was frequent menstrual irregularities. No serious adverse events were reported. CONCLUSIONS: The review shows that, emergency contraceptive regimen of single-dose levonorgestrel is not inferior in efficacy to the two-dose regimen. All the regimens studied were very efficacious for emergency contraception and prevented a high proportion of pregnancies if taken within 72 h of unprotected coitus. Single levonorgestrel dose (1.5 mg) can substitute two 0.75 mg doses 12 or 24 h apart. With either regimen, the earlier the treatment is given, the more effective it seems to be.
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