临床药理学:儿童呋喃苯胺酸的补充。
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Prandota J
临床药理学:儿童呋喃苯胺酸的补充。
2001 J。Jul-Aug; 8 (4): 275 - 89。
- PubMed ID
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11441327 (在PubMed]
- 文摘
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呋喃苯胺酸是最有效和最有毒的利尿剂用于儿科实践。实验和临床数据表明,肾上腺皮质甾类和/或内源性ouabain-like物质可能发挥重要作用在其利尿的效果。此外,药物似乎消炎。在儿童疾病接受口服或静脉注射不同剂量1 - 2毫克/公斤呋喃苯胺酸,统计上显著的积极药物之间的线性关系被发现尿排泄率和尿流率,但日志对药物剂量反应曲线被发现随疾病和药物管理局的路线。没有sigmoid-shaped日志剂量反应曲线(即一个接近零响应以非常低的呋喃苯胺酸尿排泄率和最大响应在非常高的排泄率)是获得,这可能表明,肾小管的容量diuretically应对上述剂量的呋喃苯胺酸不超过这些病人。然而,在肾功能正常的婴儿与不同的疾病和合理要求政府的利尿剂,非常陡峭的日志剂量反应曲线1毫克/公斤静脉注射剂量的呋喃苯胺酸被发现,这可能表明,高剂量可能不会导致显著增加利尿剂反应。最低的意思是呋喃苯胺酸在尿尿排泄率及其浓度显著利尿是0.58 + / - 0.33 microg /公斤/分钟和24.2 + / - 10.5 microg / ml,分别。同时,之间的显著相关性被发现的数量(毫克)呋喃苯胺酸在尿中排出在前6小时后管理和收集的尿液体积。囊性纤维化患者似乎明显更明显利尿反应平均口服剂量的0.835 + / - 0.18毫克/公斤,比在控制孩子有2毫克/公斤。儿童急性肾功能衰竭引起的急性gastroenterocolitis或肾小球肾炎,广泛的关系观察单一静脉注射剂量和利尿剂反应后管理呋喃苯胺酸(1.2至30.8毫克/公斤)。 It was suggested that the total daily dose of the drug should not exceed 100 mg in these patients. Furosemide was found to be effective in management of bronchoconstriction accompanying chronic lung disease and narrowing of the upper respiratory airways; in hydrocephalus in infancy to avoid cerebrospinal fluid shunts; in some diagnostic procedures, such as an assessment of fetal and neonatal hydronephrosis; and in evaluation of different types of renal tubular acidosis. Among side effects accompanying clinical use of this drug were cholelithiasis in premature infants receiving total parenteral nutrition concomitantly with the diuretic; secondary hyperparathyroidism and bone disease in infants obtaining long-term furosemide treatment; and drug-induced fever.
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