花生四烯酸的影响,前列腺素、维生素a、维生素a酸和维生素d3在异型生物质氧化催化了人类细胞色素P450酶。

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山崎H,岛田T

花生四烯酸的影响,前列腺素、维生素a、维生素a酸和维生素d3在异型生物质氧化催化了人类细胞色素P450酶。

Xenobiotica。1999年3月29日(3):231 - 41。doi: 10.1080 / 004982599238632。

PubMed ID

10219964 (在PubMed

]

文摘

1。花生四烯酸的影响,前列腺素、维生素a、维生素a酸和维生素d3在异型生物质氧化催化了12重组人细胞色素P450酶(P450或CYP)和由人类肝脏微粒体进行了研究。2。花生四烯酸(50 microM)显著地抑制CYP1A1和1 a2-dependent 7-ethoxycoumarin O-deethylations, CYP2C8-dependent紫杉醇6 alpha-hydroxylation CYP2C19-dependent R-warfarin 7-hydroxylation。这种化学物质也略有抑制CYP1B1异型生物质氧化催化了,2 b6, 2 c9、2 d6 2 e1和3 a4酶重组系统。3所示。视黄醇,视黄酸和维生素d3是强有力的抑制剂对异型生物质氧化催化了重组CYP1A1、2 c8和2 c19。4所示。Dixon块CYP1A1的禁忌——1 a2 - 2 c8 -和2 c19-dependent异型生物质氧化反应由花生四烯酸的CYP1A1、2 b6 - 2 c19-dependent活动视黄醇,由维生素d3和CYP1A1和2 c19-dependent活动表明,这些化学物质抑制P450活动主要通过竞争机制。5。 In human liver microsomes, arachidonic acid inhibited CYP1A2-dependent theophylline hydroxylation, CYP2C8-dependent taxol 6alpha-hydroxylation and CYP2C19-dependent omeprazole 5-hydroxylation. Taxol 6alpha-hydroxylation was also inhibited by retinol and retinoic acid, and omeprazole 5-hydroxylation was inhibited by retinol in human liver microsomes. 6. These results suggest that xenobiotic oxidations by P450 enzymes are affected by endobiotic chemicals and that the endobiotic-xenobiotic interactions as well as drug-drug interactions may be of great importance when understanding the basis for pharmacological and toxicological actions of a number of xenobiotic chemicals.

DrugBank数据引用了这篇文章

药物酶

药物	酶	类	生物	药理作用	行动
维生素d3	细胞色素P450 1 a1	蛋白质	人类	未知的	抑制剂	细节
维生素d3	细胞色素P450 2 c8	蛋白质	人类	未知的	抑制剂	细节