圣约翰草和quazepam之间的药物相互作用。
文章的细节
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引用
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川口,Ohmori M,鹤冈年代,Nishiki K,原田K, Miyamori我,矢野R,中村T,马察达米》
圣约翰草和quazepam之间的药物相互作用。
Br中国新药杂志。2004年10月,58 (4):403 - 10。doi: 10.1111 / j.1365-2125.2004.02171.x。
- PubMed ID
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15373933 (在PubMed]
- 文摘
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目的:圣约翰草(SJW)增强CYP3A4基质的CYP3A4活性和降低血药浓度。在这项研究中,苯二氮卓类药物催眠SJW的影响,quazepam, CYP3A4代谢的研究。方法:13名健康受试者单剂量了quazepam 15 mg治疗后SJW(900毫克(1))或安慰剂为14天。研究了在随机,安慰剂对照,交叉设计两者之间的间隔4周治疗。血液样本是在48小时内获得和尿液收集每次剂量的quazepam后24 h。药效学影响测定使用视觉模拟量表(血管)和数字符号替换测试(DSST)天13和14。结果:SJW等离子quazepam浓度下降。Cmax和AUC (0-48) quazepam SJW后显著低于安慰剂后[Cmax;-8.7 ng毫升(1)(95%可信区间(CI) -17.1到-0.2),AUC0-48;-55 ng h毫升(1)(95% CI -96年至-15年)]。 The urinary ratio of 6beta-hydroxycortisol to cortisol, which reflects CYP3A4 activity, also increased after dosing with SJW (ratio; 2.1 (95%CI 0.85-3.4)). Quazepam, but not SJW, produced sedative-like effects in the VAS test (drowsiness; P < 0.01, mental slowness; P < 0.01, calmness; P < 0.05, discontentment; P < 0.01). On the other hand, SJW, but not quazepam impaired psychomotor performance in the DSST test. SJW did not influence the pharmacodynamic profile of quazepam. CONCLUSIONS: These results suggest that SJW decreases plasma quazepam concentrations, probably by enhancing CYP3A4 activity, but does not influence the pharmacodynamic effects of the drug.
DrugBank数据引用了这篇文章
- 药物酶
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药物 酶 类 生物 药理作用 行动 Quazepam 细胞色素P450 3 a4 蛋白质 人类 没有底物细节