CYP1B1多态性与前列腺癌易感性:一个荟萃分析。

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李张H, L,徐Y

CYP1B1多态性与前列腺癌易感性:一个荟萃分析。

《公共科学图书馆•综合》。2013年7月4日,8 (7):e68634。doi: 10.1371 / journal.pone.0068634。打印2013。

PubMed ID

23861929 (在PubMed

]

文摘

背景:研究调查之间的联系单核苷酸多态性(snp)的细胞色素P450 1 b1 (CYP1B1)和前列腺癌(PCa)风险报告互相矛盾的结果。获得一个更精确的估计CYP1B1多态性和PCa风险之间的关系,进行荟萃分析。方法/主要结果:一个全面的文献检索进行了识别所有合格CYP1B1多态性的研究和PCa的风险。必威国际app总共14个独立研究,包括6380例病例和5807例对照,确定了。我们调查分析的影响5多态性CYP1B1 L432V(12个研究中,5999例中,有5438控制),R48G(6研究,1647例,1846控制),N453S(4研究,1407例,1499控制),-13 c / T(4研究,1116例,1114控制),和A119S(4研究,1057例,1018控制)。没有证据表明L432V与PCa在总人口有重大关联。子群分析后种族,我们发现L432V在亚洲人与PCa风险显著相关(添加剂:或= 2.38,95% ci -4.33 = 1.31, P = 0.004;隐性:或= 2.11,95% ci -3.79 = 1.17, P = 0.01;优势:或者= 1.52,95% ci -2.01 = 1.14, P = 0.004;等位基因:或= 1.52,95% ci -1.92 = 1.20, P = 0.0006)。 When stratified by source of controls, significantly elevated PCa risk was found in all genetic models in population based studies (additive: OR = 1.34, 95%CI = 1.14-1.57, P = 0.0003; recessive: OR = 1.25, 95%CI = 1.09-1.43, P = 0.002; dominant: OR = 1.25, 95%CI = 1.11-1.41, P = 0.0002; allelic: OR = 1.18, 95%CI = 1.09-1.28, P<0.0001). For N453S, there was a significant association between N453S polymorphism and PCa risk in both overall population (dominant: OR = 1.18, 95%CI = 1.00-1.38, P = 0.04) and mixed population (domiant: OR = 1.31, 95%CI = 1.06-1.63, P = 0.01; allelic: OR = 1.27, 95%CI = 1.05-1.54, P = 0.01). For A119S, our analysis suggested that A119S was associated with PCa risk under recessive model in overall population (OR = 1.37, 95%CI = 1.04-1.80, P = 0.03). CONCLUSIONS: The results suggest that L432V, N453S, and A119S polymorphisms of CYP1B1 might be associated with the susceptibility of PCa. Further larger and well-designed multicenter studies are warranted to validate these findings.

DrugBank数据引用了这篇文章

药物酶

药物	酶	类	生物	药理作用	行动
睾酮	细胞色素P450 1 b1	蛋白质	人类	未知的	底物	细节