呋喃苯胺酸(速尿灵)。药动学/药效学审查(第一部分)。

文章的细节

引用

复制到剪贴板

Ponto噢,Schoenwald RD

呋喃苯胺酸(速尿灵)。药动学/药效学审查(第一部分)。

Pharmacokinet。1990; 18 (5): 381 - 408。doi: 10.2165 / 00003088-199018050-00004。

PubMed ID

2185908 (在PubMed

]

文摘

呋喃苯胺酸(速尿灵)是一个有效的循环中使用利尿剂治疗水肿的状态与心脏有关,肾和肝衰竭,用于治疗高血压。治疗通常是口服摄入明显不稳定的系统可用性的复杂和不可预测的反应用量。行动的确切机制还没有完全理解,但呋喃苯胺酸被认为行为在支架表面提升肢体的亨利循环通过抑制活性氯的重吸收。给定的响应剂量液体和电解质平衡调制的个人。急性和延迟容忍已经证明在动物和人,并假定是由于体内平衡机制的干预影响液体和电解质平衡。呋喃苯胺酸是交付给其网站的行动积极通过非特异性分泌有机酸泵。对比观察利尿/尿食盐排泄和等离子呋喃苯胺酸浓度,尿排泄率和肾清除率发现消极的或没有相关性血浆药物浓度与尿液测量但重要的关联。响应与尿液中药物的浓度而不是在等离子体。最常见的不良反应可归因于速尿治疗基本上是扩展的治疗效果(即液体和电解质紊乱)。呋喃苯胺酸的药代动力学行为发生了很大程度的变化,源于差异和两国学科和研究协议。 Part of this variability can be attributed to differences in organ function, which is important in view of the types of patients treated with furosemide. On the other hand, a large proportion remains as inter- and intrasubject variation. The bioavailability of furosemide from oral dosage forms is highly variable. The poor bioavailability has been hypothesized to be due to the poor solubility of the compound, site-specific absorption, presystemic metabolism and/or other unknown mechanisms. Furosemide is highly bound to plasma proteins, almost exclusively to albumin. Although the drug is insoluble in water and favours partitioning into fatty tissue, the high degree of plasma protein binding restricts the apparent volume of distribution at steady-state to values within a multiple of 2 to 5 times the plasma volume. Furosemide has two documented metabolites--furosemide glucuronide and saluamine (CSA). The first is an accepted metabolic product, whereas the status of CSA as a metabolite is highly controversial.(ABSTRACT TRUNCATED AT 400 WORDS)

DrugBank数据引用了这篇文章

药物

呋喃苯胺酸