舍曲林CYP2B6和CYP2C19多态性的影响抑郁症患者的代谢。

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Yuce-Artun N, Baskak B, Ozel-Kizil ET,奥兹德米尔H, Uckun Z, Devrimci-Ozguven H, Suzen海关

舍曲林CYP2B6和CYP2C19多态性的影响抑郁症患者的代谢。

Int中国制药。2016年4月,38 (2):388 - 94。doi: 10.1007 / s11096 - 016 - 0259 - 8。Epub 2016年1月30日。

PubMed ID

26830411 (在PubMed

]

文摘

背景:在CYP2B6和CYP2C19基因多态性可能导致舍曲林的新陈代谢的变化,一种广泛使用的抗抑郁药在治疗重度抑郁症。摘要目的:本研究调查的影响CYP2B6 * 4 (785 > G), CYP2B6 * 9 (516 G > T), CYP2B6 * 6 (516 G > T + 685 G > A) CYP2C19 * 2 (685 G > A), CYP2C19 * 17 (-3402 c > T)多态性在等离子体浓度的舍曲林和N-desmethyl舍曲林与舍曲林治疗抑郁症患者(n = 50)。设置:参与者的病人承认成人大学医院精神科门诊单位。这些都是dsm - iv诊断抑郁症患者稳定的舍曲林治疗方案(至少一个月)。方法:CYP2B6 * 4 (rs 2279343;785 > G), CYP2B6 * 9 (516 G > T;rs 3745274), CYP2B6 * 6 (516 g > T + 685 g > A) CYP2C19 * 2 (rs 4244285;685 g > A), CYP2C19 * 17 (rs 11188072;-3402 c > T)多态性进行了分析通过聚合酶链反应和限制性片段长度多态性。等离子体浓度的高效液相色谱测定患者在泽特。 MAIN OUTCOME MEASURE: The distribution of CYP2B6*4, *6, *9 and CYP2C19*2, *17 among patient group and the association between genotype and sertraline metabolism. RESULTS: Sertraline, N-desmethyl sertraline, N-desmethyl sertraline/sertraline and dose-adjusted plasma concentrations were statistically compared between individuals with wild-type and variant alleles both for CYP2B6 and CYP2C19 enzymes. The mean N-desmethyl sertraline/sertraline value, was significantly lower in all subgroups with *6 and *9 variant alleles (p < 0.05). Sertraline/C values were significantly higher (p < 0.05) and N-desmethyl sertraline/C values were lower in all subgroups with *6 and *9 variant alleles compared to wild-type subgroup. CONCLUSION: CYP2B6*6 and *9 variant alleles had a significant decreasing effect on sertraline metabolism in major depression patients which might result as variations in sertraline therapy.

DrugBank数据引用了这篇文章

药物酶

药物	酶	类	生物	药理作用	行动
舍曲林	细胞色素P450 2 b6	蛋白质	人类	未知的	底物 抑制剂	细节
舍曲林	细胞色素P450 2 c19	蛋白质	人类	未知的	底物 抑制剂	细节