症状改善经前焦虑障碍与舍曲林治疗。一个随机对照试验。舍曲林经前焦虑的协作学习小组。

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扬克斯KA Halbreich U,弗里曼E,布朗C,恩迪科特J,弗兰克•E帕里B, Pearlstein T,塞韦里诺,结实的,石头,哈里森W

症状改善经前焦虑障碍与舍曲林治疗。一个随机对照试验。舍曲林经前焦虑的协作学习小组。

《美国医学协会杂志》上。1997年9月24日,278 (12):983 - 8。

PubMed ID

9307345 (在PubMed

]

文摘

背景:经前焦虑障碍是一个重要的导致经期妇女的症状和功能障碍。目的:评价盐酸舍曲林治疗经前烦躁不安的效果通过测量变化表达和功能障碍症状。设计:两个筛选周期紧接着1单盲安慰剂周期和3周期的随机、双盲、安慰剂治疗。设置:十二个大学附属门诊精神病学和妇科诊所。病人:447年的女性要求参与,243遇到标准经前焦虑障碍和随机;200名女性完成了研究。干预:一个灵活的(50 - 150毫克)盐酸舍曲林的日剂量。主要结果测量:每日的记录问题的严重性,汉密尔顿抑郁量表、临床全球规模的印象,和社会调整的规模。结果:意思是(+ / -标准差)每日总症状评分显著下降(P <措施)sertraline-treated(64 + 44 + / -19 / -22)与安慰剂组相比(62 + 54 + / -24 / -22)组。显著改善(P < . 05)被发现的所有临床派生症状簇(抑郁、物理和愤怒/易怒症状)。 Hamilton Rating Scale for Depression scores decreased by 44% and 29% in the sertraline and placebo groups, respectively (P<.002). End-point global ratings showed much or very much improvement in 62% of the active treatment group and 34% of the placebo treatment group (P<.001). Reported functional impairment was substantial at baseline. Improvement in psychosocial functioning with treatment was similar to what is found in studies of major depression. CONCLUSIONS: Sertraline was significantly better than placebo for treatment of premenstrual dysphoria as reflected by symptomatic improvement and change in reported functional impairment. Serotonin reuptake inhibitors such as sertraline are useful therapeutic options for women with premenstrual dysphoria.

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药物

舍曲林