多中心、随机、双盲、安慰剂对照试验的thiocolchicoside急性下腰痛。

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Tuzun F, Unalan H,无比的人N, Ozguzel H, Kirazli Y, Icagasioglu, Kuran B, Tuzun年代,Basar G

多中心、随机、双盲、安慰剂对照试验的thiocolchicoside急性下腰痛。

关节骨脊柱。2003年9月,70 (5):356 - 61。

PubMed ID

14563464 (在PubMed

]

文摘

摘要目的:探讨肌内注射的功效thiocolchicoside (4 mg-2毫升)与安慰剂相比管理连续5天每天两次的病人患有急性下腰痛。患者和方法:多中心,随机,双盲,安慰剂对照试验。这项研究是1998年7月至2000年3月进行五个中心。包括急性下腰痛患者住院。主要的评价标准是自发疼痛静止评估视觉模拟量表(血管)。强度Hand-to-floor距离,肌肉痉挛,患者的全球评估和镇痛平板(扑热息痛)消费被用作二级评价标准。结果:一百四十九名患者。两组显示改善自发性疼痛评估血管的第一天;然而,改善thiocolchicoside小组第三天达到统计上的显著水平(P < 0.001)。Hand-to-floor距离和肌肉痉挛由触诊第五天thiocolchicoside组显著降低(P < 0.0005)。 According to the patients' global evaluation, 76.8% of patients in thiocolchicoside group evaluated the treatment as very good/good (P < 0.0005). Also a significant difference was observed in favor of the thiocolchicoside group in the total paracetamol consumption (P < 0.001). Treatment was well tolerated in both groups and none of the patients was withdrawn from the study due to an adverse effect. CONCLUSION: Twice daily administration of 4 mg thiocolchicoside for 5 days provides an efficient and safe treatment for patients with acute low back pain accompanied by muscle spasm.

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药物

Thiocolchicoside