echinacoside代谢,抗氧化剂,在老鼠:胆汁代谢产物的分离和鉴定。

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张贾C, H,金W, K,江Y,赵M,你P

echinacoside代谢,抗氧化剂,在老鼠:胆汁代谢产物的分离和鉴定。

药物金属底座Dispos。2009年2月,37 (2):431 - 8。doi: 10.1124 / dmd.108.023697。Epub 2008 11月20。

PubMed ID

19022941 (在PubMed

]

文摘

Echinacoside(决定)的一个主要活动信息(挂钩)著名的中药,大芸。虽然它有多种生物活性,如抗氧化、神经保护、和hepatoprotection,了解其代谢的命运是不足。在目前的研究中,八个二期代谢物,3、4 -O-dimethyl-ECH-3 -O-beta-d-glucuronide (M1);4、4 -O-dimethyl-ECH-3 -O-beta-d-glucuronide (M2);3、4 -O-dimethyl-ECH-4-O-sulfate酯(M3);4、4 -O-dimethyl-ECH-3-O-sulfate酯(M4);3、3 -O-dimethyl-ECH (M5);3、4 -O-dimethyl-ECH (M6);4、3 -O-dimethyl-ECH (M7);和4 4 -O-dimethyl-ECH (M8),静脉注射后大鼠胆汁样品中分离的管理决定,通过质谱和核磁共振光谱,包括(1)H NMR (13) C NMR,核光谱奥佛好塞效应差异,和二维核磁共振(异核单量子关联,杂环的多重键关联能谱法,gradient-selected相关光谱和核奥佛好塞效应谱)。 Among them, M5 to M8 were O-di-methylated conjugates; M1 and M2 and M3 and M4 were O-dimethyl glucuronides and O-dimethyl sulfates, respectively. In the three types of metabolites of rat, the major metabolites were the methyl ethers and the glucuronides, whereas the sulfates were minor. The regioselectivity of conjugation for ECH and metabolic pathway of ECH were proposed, which gave insight into the mechanism of ECH for its bioactivities in vivo.

DrugBank数据引用了这篇文章

药物

Echinacoside

药物酶

药物	酶	类	生物	药理作用	行动
Echinacoside	儿茶酚O-methyltransferase	蛋白质	人类	未知的	底物	细节