体内成像的淀粉样蛋白沉积在阿尔茨海默病用放射性配体18 f-av-45 (florbetapir(纠正)F 18)。
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黄DF,罗森博格PB,周Y,库马尔,Raymont V, Ravert HT, Dannals射频,南帝,识小,你们W,希尔顿J, Lyketsos C,龚高频,Joshi广告,Skovronsky DM, Pontecorvo乔丹
体内成像的淀粉样蛋白沉积在阿尔茨海默病用放射性配体18 f-av-45 (florbetapir(纠正)F 18)。
51 J诊断。2010年6月;(6):913 - 20。doi: 10.2967 / jnumed.109.069088。
- PubMed ID
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20501908 (在PubMed]
- 文摘
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(18)F-labeled宠物淀粉样β蛋白(β淀粉状蛋白质)显像剂可以促进老年认知障碍的临床评估通过提供一个客观的衡量阿尔茨海默病(AD)病理学。这里我们给临床试验的结果(E) 4 - (2 - (6 - (2 - (2 - (2 - (18) F-fluoroethoxy)乙氧基)乙氧基的)pyridin-3-yl)乙烯基)-N-methy l benzenamine ((18) F-AV-45或florbetapir(纠正)F 18)。方法:一个非盲、多通道脑成像、新陈代谢,和安全的研究(18)F-AV-45 AD患者(16日进行细微精神状态检查得分,19.3 + / - 3.1;平均年龄+ / - SD, 75.8 + / - 9.2 y)和16个认知健康对照组(高碳钢)(细微精神状态检查得分,29.8 + / - 0.45;平均年龄+ / - SD, 72.5 + / - 11.6 y)动态宠物进行一段大约90分钟后注入示踪剂的(370兆贝可[10 mCi])。标准摄入值和cortical-to-cerebellum标准摄入值比率(SUVRs)计算。组织一个简化的参考方法用于生成分布体积比(DVR)参数映射为主题的一个子集。结果:有效的宠物数据用于11 AD患者和15高碳钢。(18)F-AV-45积累皮质区域将高β淀粉状蛋白质沉积(例如,楔前叶和额叶和颞皮层)在AD患者;示踪剂的最小累积在高碳钢的皮层区域。 The cortical-to-cerebellar SUVRs in AD patients showed continual substantial increases through 30 min after administration, reaching a plateau within 50 min. The 10-min period from 50 to 60 min after administration was taken as a representative sample for further analysis. The cortical average SUVR for this period was 1.67 +/- 0.175 for patients with AD versus 1.25 +/- 0.177 for HCs. Spatially normalized DVRs generated from PET dynamic scans were highly correlated with SUVR (r = 0.58-0.88, P < 0.005) and were significantly greater for AD patients than for HCs in cortical regions but not in subcortical white matter or cerebellar regions. No clinically significant changes in vital signs, electrocardiogram, or laboratory values were observed. CONCLUSION: (18)F-AV-45 was well tolerated, and PET showed significant discrimination between AD patients and HCs, using either a parametric reference region method (DVR) or a simplified SUVR calculated from 10 min of scanning 50-60 min after (18)F-AV-45 administration.
