植物多酚姜黄素显著影响CYP1A2和体内CYP2A6基因表现活动健康,中国男性志愿者。

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陈Y,刘WH,陈提单、风扇L,汉族Y,王G,胡锦涛DL,谭锆、周G,曹年代,周HH

植物多酚姜黄素显著影响CYP1A2和体内CYP2A6基因表现活动健康,中国男性志愿者。

安Pharmacother。2010年6月,44 (6):1038 - 45。doi: 10.1345 / aph.1M533。2010年5月18日Epub。

PubMed ID

20484172 (在PubMed

]

文摘

背景:姜黄素是一种植物多酚,是从姜黄的根茎中提取的。研究姜黄素的影响在人类是摘要的活动缺乏。摘要目的:探讨姜黄素对CYP1A2的活动的影响,体内CYP2A6基因表现,N-acetyltransferase (NAT2),和黄嘌呤氧化酶(XO)体内,使用咖啡因作为探针药物。方法:16无关的,健康的中国男人参与了这一研究。有两个阶段的研究。在第一阶段,志愿者们口头接受100毫克咖啡因和0 - 12小时的血液和尿液样本收集。在第二阶段,志愿者们收到1000毫克姜黄素每天一次,连续使用14天,和血液和尿液样本收集15天,遵循同样的步骤在第一天使用。尿咖啡因代谢物比值被用作CYP1A2的活动的指标,体内CYP2A6基因表现,NAT2, XO。咖啡因的药物及其代谢产物的高效液相色谱测定。结果:curcumin-treated组,CYP1A2活性下降了28.6%(95%可信区间15.6到41.8; p < 0.000), while increases were observed in CYP2A6 (by 48.9%; 95% CI 25.3 to 72.4; p < 0.000). Plasma area under the curve from zero to 12 hours of 1,7-dimethylxanthine (17X) was decreased by 27.2% (95% CI 6.1 to 48.3; p = 0.014). The urinary excretion of 17X and 1-methylxanthine was significantly decreased by 36.4% (95% CI 19.4 to 53.6; p < 0.000) and 31.2% (95% CI 8.5 to 54.1; p = 0.010), respectively. The excretion of 1,7-dimethylurate (17U) was significantly increased by 77.3% (95% CI 5.6 to 148.8; p = 0.036). No significant changes were observed for caffeine, 1-methylurate, and 5-acetylamino-6-formylamino-3-methyluracil between the 2 study phases. CONCLUSIONS: The results indicated that curcumin inhibits CYP1A2 function but enhances CYP2A6 activity. Simultaneously, some pharmacokinetic parameters relating to 17X were affected by curcumin. If this finding is confirmed by other studies, the possibility of herb-drug interactions associated with curcumin should be considered in clinical practice.

DrugBank数据引用了这篇文章

药物酶

药物	酶	类	生物	药理作用	行动
姜黄素硫酸盐	细胞色素P450 1 a2	蛋白质	人类	未知的	抑制剂	细节