68 ga-dotatoc与68 ga-dotatate PET / CT在神经内分泌肿瘤功能成像。
文章的细节
-
引用
复制到剪贴板 -
Poeppel TD, Binse我Petersenn年代,Lahner H, Schott M, Antoch G, Brandau W, Bockisch,男孩C
68 ga-dotatoc与68 ga-dotatate PET / CT在神经内分泌肿瘤功能成像。
J诊断。2011年12月,52 (12):1864 - 70。doi: 10.2967 / jnumed.111.091165。Epub 2011年11月9日。
- PubMed ID
-
22072704 (在PubMed]
- 文摘
-
未标记的:放射性标记的生长抑素类似物代表有价值的工具对体内神经内分泌肿瘤的诊断和治疗(网),因为频繁的tumoral过度生长激素抑制素受体(sst)。2化合物最常用的功能成像与宠物Ga-DOTATATE(68)和(68)Ga-DOTATOC。两个配体有着非常相似的sst绑定配置。然而,(68)的体外亲和力Ga-DOTATATE绑定对海温亚型2 (sst2)大约是10倍高于(68)Ga-DOTATOC。这种差异可能会影响他们在净病变的检测效率,因为它是sst2主要是在网络。我们因此而PET / CT的诊断价值与放射性标记的生长抑素类似物(Ga-DOTATATE(68)和(68)Ga-DOTATOC)在同一病人。方法:40例转移性网接受Ga-DOTATOC(68)和(68)Ga-DOTATATE PET / CT的检查之前潜在肽受体放射性核素治疗。这两种成像方法的性能进行了分析和比较每个病人个人损伤的检测和8定义身体区域。一个地区被认为积极如果至少1损伤检测。此外,radiopeptide吸收的(SUVmax)最大的标准吸收值比较一致的病变和肾实质。 RESULTS: Seventy-eight regions were found positive with (68)Ga-DOTATATE versus 79 regions with (68)Ga-DOTATOC (not significant). Overall, however, significantly fewer lesions were detected with (68)Ga-DOTATATE than with (68)Ga-DOTATOC (254 vs. 262, P < 0.05). Mean (68)Ga-DOTATATE SUVmax across all lesions was significantly lower than (68)Ga-DOTATOC (16.0 +/- 10.8 vs. 20.4 +/- 14.7, P < 0.01). Mean SUVmax for renal parenchyma was not significantly different between (68)Ga-DOTATATE and (68)Ga-DOTATOC (12.7 +/- 3.0 vs. 13.2 +/- 3.3). CONCLUSION: (68)Ga-DOTATOC and (68)Ga-DOTATATE possess a comparable diagnostic accuracy for the detection of NET lesions, with (68)Ga-DOTATOC having a potential advantage. The approximately 10-fold higher affinity for the sst2 of (68)Ga-DOTATATE does not prove to be clinically relevant. Quite unexpectedly, SUVmax of (68)Ga-DOTATOC scans tended to be higher than their (68)Ga-DOTATATE counterparts.
DrugBank数据引用了这篇文章
- 药物