舍曲林与抑郁症的其他抗抑郁的药物。
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Cipriani A La Ferla T,助教,古河道Signoretti,中川,丘吉尔R, McGuire H, Barbui C
舍曲林与抑郁症的其他抗抑郁的药物。
科克伦数据库系统启2010 1月20;(1):CD006117。doi: http://dx.doi.org/10.1002/14651858.CD006117。
- PubMed ID
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20091586 (在PubMed]
- 文摘
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背景:美国国家健康和临床研究所临床实践指南对抑郁症的治疗建议选择性5 -羟色胺再摄取抑制剂药物治疗时应一线选项显示抑郁发作。初步证据表明,舍曲林可能稍微的疗效更佳。目的:评估疗效的证据,可接受性和耐受性舍曲林与三环抗抑郁药(TCAs)相比,杂环,其他SSRIs和新代理的急性期治疗抑郁症。必威国际app搜索策略:MEDLINE (1966 - 2008)、EMBASE (1974 - 2008), Cochrane协作抑郁,焦虑和神经症对照试验注册和Cochrane中央注册2008年7月的对照试验。没有语言限制应用。参考列表相关的文件和以前的系统评价是hand-searched。必威国际app制药公司和专家在这个领域联系补充数据。选择标准:抑郁症患者随机对照试验分配舍曲林与其他抗抑郁的代理。数据收集和分析:两个评论作者独立提取数据。差异是与另一个团队的成员来解决。 A double-entry procedure was employed by two reviewers. Information extracted included study characteristics, participant characteristics, intervention details and outcome measures in terms of efficacy (the number of patients who responded or remitted), acceptability (the number of patients who failed to complete the study) and tolerability (side-effects). MAIN RESULTS: A total of 59 studies, mostly of low quality, were included in the review, involving multiple treatment comparisons between sertraline and other antidepressant agents. Evidence favouring sertraline over some other antidepressants for the acute phase treatment of major depression was found, either in terms of efficacy (fluoxetine) or acceptability/tolerability (amitriptyline, imipramine, paroxetine and mirtazapine). However, some differences favouring newer antidepressants in terms of efficacy (mirtazapine) and acceptability (bupropion) were also found. In terms of individual side effects, sertraline was generally associated with a higher rate of participants experiencing diarrhoea. AUTHORS' CONCLUSIONS: This systematic review and meta-analysis highlighted a trend in favour of sertraline over other antidepressive agents both in terms of efficacy and acceptability, using 95% confidence intervals and a conservative approach, with a random effects analysis. However, the included studies did not report on all the outcomes that were pre-specified in the protocol of this review. Outcomes of clear relevance to patients and clinicians were not reported in any of the included studies.
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- 药物