舍曲林在脑卒中后抑郁治疗和预防中的作用:一项荟萃分析。

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冯锐，王鹏，高超，杨杰，陈忠，杨勇，焦杰，李敏，付波，李林，张震，王松

舍曲林在脑卒中后抑郁治疗和预防中的作用:一项荟萃分析。

医学(巴尔的摩)。2018年12月,97年(49):e13453。doi: 10.1097 / MD.0000000000013453。

PubMed ID

30544429 (PubMed视图

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摘要

背景:卒中后抑郁(PSD)的发病率在世界范围内仍然很高。此外，PSD会引起多种后遗症。虽然舍曲林已被报道有效治疗PSD，但许多研究仍不一致。方法:PubMed、Embase、Scopus、Cochrane中央对照试验登记册、临床试验。检索数据包括:万方数据(中文)、维普数据(中文)、中国知网(中文)。纳入符合本研究纳入标准的随机对照试验(rct)和自我对照试验(SCTs)。评估抑郁评分、PSD发生率、日常生活活动(ADL)、神经功能障碍评分及不良反应。结果:在我们的工作中招募了大约11项研究，包括1258名参与者。对于纳入的试验，结果描述为:舍曲林组抑郁评分显著降低(WMD -6.38;95% CI -8.63至-4.14; P < .00001); the incidence of PSD was significantly lower in sertraline groups (RR 0.48; 95%CI 0.35-0.67; P < .0001); there was obvious improvement of ADL (WMD 11.48; 95% CI 4.18-18.78; P = .002 <0.05) and neurological impairment (WMD -3.44; 95% CI -6.66 to -0.21; P = .04 <0.05); no significant difference between sertraline and control groups in the morbidity of adverse events (RR 0.94; 95% CI 0.83-1.06; P = .33 >0.05). However, in sensitivity analyses, the conclusions of the reduction of depression rating scores and the improvement of ADL were altered. CONCLUSIONS: The study suggests that sertraline has a potentially protective role compared with control groups and demonstrates sertraline is safe. However, the reduction of depression rating scores and the improvement of ADL should be considered carefully.

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舍曲林