不良事件与术中注射isosulfan蓝色。

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戴利博士诺曼PH值、泄漏JA阮DT, Bui TP,科瓦尔斯基,Srejic U, Popat K,阿伦斯摩根富林明,Gershenwald我,亨特KK, Kuerer嗯

不良事件与术中注射isosulfan蓝色。

中国Anesth。2004年8月,16 (5):332 - 41。

PubMed ID

15374553 (在PubMed

]

文摘

研究目的:描述相关的不良事件的术中注射isosulfan蓝在一大群病人有一个广泛的外科手术,并确定这些事件的危险因素。设计:回顾性图表回顾。背景:大学附属机构专门从事恶性肿瘤患者:1835代表1852手术病人。测量:发生率、类型、严重程度、发生时间、持续时间、管理和不良事件的潜在风险因素的存在。事件被认为是“主要”如果可能危及生命的低血压发生。主要结果:不良事件发生在28程序(1.5%)和14这些不良事件(0.75%)归类为主要。事件的类型是:21患者皮肤反应,低血压在14个病人,水肿1例,1例未指明的。不良事件发生的时间为42.2 + / - 53.9分钟(平均17.5;范围1 - 180分钟)isosulfan蓝注射后,和大大延长了轻微的反应与重大事件(p = 0.015)。最长的不良事件持续了至少21小时。 Treatment was successful with usual antiallergy/antianaphylaxis medications. Ten patients received diphenhydramine alone, and four patients received intravenous epinephrine infusions. Factors associated with a significantly increased incidence of adverse events were isosulfan blue injection in the vulvar area (p = 0.000038), and the chronic preoperative use of angiotensin-converting enzyme inhibitors or angiotensin receptor-blocking agents (p = 0.043). Trends toward an increased risk of an adverse event were noted with isosulfan blue injection in the breast area (p = 0.19), and having more than one surgical procedure with isosulfan blue (p = 0.14). CONCLUSIONS: Although the most frequent adverse event associated with injection of isosulfan blue was a skin reaction, potentially life-threatening hypotension occurred in 0.75% of all procedures. Anesthesiologists must be aware of the variable onset time and potentially prolonged duration of the adverse events. They should recognize the need for extra vigilance in patients with potential risk factors, and have the usual antiallergy/antianaphylaxis medications available for administration if necessary.

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药物

Isosulfan蓝色