单剂量口服meloxicam成人急性术后疼痛。

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德里摩尔RA,年代,人尽其才HJ

单剂量口服meloxicam成人急性术后疼痛。

科克伦数据库系统启2009 10月7;(4):CD007552。cd007552.pub2 doi: 10.1002/14651858.。

PubMed ID

19821429 (在PubMed

]

文摘

背景:Meloxicam是一种非甾体抗炎药(非甾体抗炎药)主要用于治疗风湿性关节炎相关的疼痛。通常的骨关节炎口服剂量为每天15毫克,但低剂量的7.5毫克和老年患者的建议。本文试图评估口腔meloxicam急性术后疼痛的临床疗效和安全性,使用临床研究建立患者的疼痛,和结果的测量主要是超过6小时使用标准的方法。这种类型的研究已被用于许多几十年建立药物镇痛属性。目的:评估单剂量口服meloxicam的功效在急性术后疼痛,和任何相关的不良事件。必威国际app搜索策略:我们在Cochrane中央(问题2,2009),MEDLINE(2009年6月);EMBASE(2009年6月);牛津止痛数据库。选择标准:随机、双盲、安慰剂对照的临床试验口服meloxicam成人急性术后疼痛的缓解。数据收集和分析:两个评论作者独立评估试验质量和提取数据。 We planned to use area under the "pain relief versus time" curve to derive the proportion of participants with meloxicam experiencing least 50% pain relief over 4 to 6 hours, using validated equations; to use number needed to treat to benefit (NNT); the proportion of participants using rescue analgesia over a specified time period; time to use of rescue analgesia; information on adverse events and withdrawals. MAIN RESULTS: No studies were identified by the searches that examined oral meloxicam in patients with established postoperative pain. AUTHORS' CONCLUSIONS: In the absence of evidence of efficacy, at present, for oral meloxicam in acute postoperative pain, its use in this indication is not justified. Because trials clearly demonstrating analgesic efficacy in the most basic of acute pain studies is lacking, use in other indications should be evaluated carefully. Given the large number of available drugs of this and similar classes, there is no urgent research agenda.

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药物

Meloxicam